1. GPCR/G Protein
  2. mGluR

FPTQ 

Cat. No.: HY-100382 Purity: 99.89%
Handling Instructions

FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.

For research use only. We do not sell to patients.

FPTQ Chemical Structure

FPTQ Chemical Structure

CAS No. : 864863-72-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 282 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. Inhibit [3H] FTIDC target: mGluR1 IC 50: 6 nM [1] In vivo: FPTQ exhibited dose-dependent and plasma concentration- dependent receptor occupancy in the cerebellum and striatum. Compound A inhibit (S)-3,5-DHPG-induced face-washing behavior by 46 ± 14% and 97 ± 6.6% (mean ± S.E.M., n = 6) at 10 and 30 mg/kg, respectively.[2]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2754 mL 16.3768 mL 32.7536 mL
5 mM 0.6551 mL 3.2754 mL 6.5507 mL
10 mM 0.3275 mL 1.6377 mL 3.2754 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

305.31

Formula

C₁₇H₁₂FN₅

CAS No.

864863-72-9

SMILES

FC(N=CC=C1)=C1N2N=NC(C3=CC4=C(C=C3)N=CC=C4)=C2C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
FPTQ
Cat. No.:
HY-100382
Quantity:

FPTQ

Cat. No.: HY-100382