mGluR3

mGluR3 Related Products (34):

By Type:	Pan (17) Selective (9)
By Effects:	Inhibitors (2) Agonists (17) Antagonists (9) Activators (2) Modulators (4)

Cat. No.	Product Name	Effect	Purity

HY-W014666

Xanthurenic acid	Agonist	99.53%
Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.

HY-70059

LY341495	Antagonist	99.96%
LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC₅₀s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively.

HY-103558

LY379268	Agonist	99.84%
LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC₅₀ values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects.

HY-W015546

β-N-methylamino-L-alanine hydrochloride	Activator	98.0%
β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. β-N-methylamino-L-alanine hydrochloride activates mGluR3 and inhibits PKC. β-N-methylamino-L-alanine hydrochloride can be used in the research of neurodegenerative diseases and immune diseases.

HY-18941

Eglumegad	Agonist	99.94%
Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC₅₀s of 5 nM and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.

HY-131292

Ro-65-3479	Antagonist
Ro-65-3479 is a selective metabotropic glutamate receptor (mGlu2/3) antagonist. Ro-65-3479 blocks glutamate-induced signaling and modulates calcium channel activity. Ro-65-3479 is promising for research of disorders involving glutamatergic dysregulation, such as anxiety, schizophrenia, and neurodegenerative diseases.

HY-131286

Talaglumetad	Activator
Talaglumetad (LY-544344) is a prodrug of mGlu2/3 receptor agonist Eglumetad (HY-18941). Talaglumetad exhibits anxiolytic activity and reverses fear-induced suppression of operant responding. Talaglumetad shows anxiolytic effects in CCK-4-induced panic and anxiety studies. Talaglumetad can be used in studies on the mechanisms associated with generalized anxiety disorder.

HY-131288

LY2934747	Agonist
LY2934747 is a selective and blood-brain barrier-permeable dual mGlu2/mGlu3 receptor agonist, with K_i values of 260 nM and 177 nM, and EC₅₀ values of 8.4 nM and 62.4 nM against human receptors, respectively. LY2934747 exhibits antipsychotic and analgesic activities in in vivo animal models. LY2934747 can be used in studies related to psychosis and pain.

HY-119243

LY2794193	Agonist	99.65%
LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 K_i=0.927 nM，EC₅₀=0.47 nM; hmGlu2 K_i=412 nM，EC₅₀=47.5 nM).

HY-108710

VU0650786	Antagonist	99.55%
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC₅₀ of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.

HY-122138

VU6010572	Modulator	99.88%
VU6010572 is a potent, selective and brain-penetrant mGlu3 negative allosteric modulator with IC₅₀ of 245 nM. VU6010572 is highly CNS penetrant.

HY-120717

VU6001966	Inhibitor	99.89%
VU6001966 is a brain-penetrant and selective mGlu2 receptor inhibitor. VU6001966 blocks mGlu2 receptor activity, counteracts LY379268 (HY-103558)-mediated blood-brain barrier protection and inflammatory cytokine dampening in microglia under inflammatory conditions. VU6001966 enhances antidepressant effects when combined with Scopolamine (HY-N0296). VU6001966 can be used for the research of major depressive disorder.

HY-50906

LY404039	Agonist	98.0%
LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with K_is of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects.

HY-101335

DCG-IV	Agonist	99.0%
DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.

HY-105040C

Pomaglumetad methionil hydrochloride	Agonist	98.0%
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.

HY-16766

Decoglurant	Modulator	99.71%
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.

HY-19630

ML289	Inhibitor	98.29%
ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC₅₀=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123820

LY3020371 hydrochloride	Antagonist	99.18%
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with K_i of 5.3 and 2.5 nM, potently blocks cAMP formation with IC₅₀ of 16.2 nM. LY3020371 hydrochloride exerts an antidepressant-like signature in vivo.

HY-16636

ML337	Modulator	99.04%
ML337 is a selective and brain-penetrant negative allosteric modulator of mGlu3, with an IC₅₀ of 593 nM. ML337 possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile. ML337 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131286A

Talaglumetad hydrochloride	Agonist	99.58%
Talaglumetad (LY-544344) hydrochloride is a prodrug of mGlu2/3 receptor agonist Eglumetad (HY-18941). Talaglumetad hydrochloride exhibits anxiolytic activity and reverses fear-induced suppression of operant responding. Talaglumetad hydrochloride shows anxiolytic effects in CCK-4-induced panic and anxiety studies. Talaglumetad hydrochloride can be used in studies on the mechanisms associated with generalized anxiety disorder.

Name
Email *

	Sorry, but the email address you supplied was invalid.