2126784-39-0
2126784-39-0
Chemical Structure
VU6010572
- CAS No.: 2126784-39-0
- Formula:C20H18FNO3
- Molecular Weight:339.36
IUPAC Name: (S)-1-(4-fluorophenyl)-4-(2-phenoxypropoxy)pyridin-2(1H)-one
InChIKey: AUMJXOXUSGIUCB-HNNXBMFYSA-N
SMILES: O=C1C=C(OC[C@@H](OC2=CC=CC=C2)C)C=CN1C3=CC=C(F)C=C3
Biological Activity: VU6010572 is a potent, selective and brain-penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2].
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VU6010572 | 99.88% | VU6010572 is a potent, selective and brain-penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant. | ||||||||||||||||||||
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References
- [1]. Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15. [Content Brief]
- [2]. Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST
Keywords
