IL-22 Receptor
IL-22 Receptor is a type 2 cytokine receptor comprised of the heterodimeric complex with IL-22RA1 and IL-10R2. IL-22 Receptor is the member of the IL-10 family of receptors along with the receptors for IL-10, IL-19, IL-20, IL-24, IL-26, IL-28 and IL-29[1]. IL-22 Receptor interacts with IL-22 signaling via JAK/STAT pathways. IL-22 Receptor inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis[2]. IL-22R expression is characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases[3].
- [1]. Dudakov JA, et, al. Interleukin-22: immunobiology and pathology. Annu Rev Immunol. 2015;33:747-85. [Content Brief]
- [2]. Cui X, et, al. IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling. Oncol Rep. 2019 Apr;41(4):2148-2158. [Content Brief]
- [3]. Akil H, et, al. IL22/IL-22R pathway induces cell survival in human glioblastoma cells. PLoS One. 2015 Mar 20;10(3):e0119872. [Content Brief]
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IL-22 Receptor Recombinant Proteins (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
