IL-22 Receptor

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IL-22 Receptor

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IL-22 Receptor is a type 2 cytokine receptor comprised of the heterodimeric complex with IL-22RA1 and IL-10R2. IL-22 Receptor is the member of the IL-10 family of receptors along with the receptors for IL-10, IL-19, IL-20, IL-24, IL-26, IL-28 and IL-29^[1]. IL-22 Receptor interacts with IL-22 signaling via JAK/STAT pathways. IL-22 Receptor inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis^[2]. IL-22R expression is characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases^[3].

References:

[1]. Dudakov JA, et, al. Interleukin-22: immunobiology and pathology. Annu Rev Immunol. 2015;33:747-85. [Content Brief]

[2]. Cui X, et, al. IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling. Oncol Rep. 2019 Apr;41(4):2148-2158. [Content Brief]

[3]. Akil H, et, al. IL22/IL-22R pathway induces cell survival in human glioblastoma cells. PLoS One. 2015 Mar 20;10(3):e0119872. [Content Brief]

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IL-22R alpha 1 (7)

IL-22 Receptor Recombinant Proteins (9)

Species:	Human (3) Mouse (1) Rat (2) Canine (2) Cynomolgus (1)
Tag:	His (3) Fc (6) Avi (2)
Source:	HEK293 (9)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P77967

IL-22R alpha 1 Protein, Human (HEK293, Fc) IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11	Human	HEK293
IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Human (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (H16-T228) with a Fc tag at the C-terminus.

HY-P77424

IL-22R alpha 1 Protein, Canine (HEK293, His) Interleukin-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9; ZcytoR11; IL22R	Canine	HEK293
IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Canine (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (M1-The226) with a His tag at the C-terminus.

HY-P77001

IL-22R alpha 1 Protein, Rat (HEK293, Fc) Interleukin-22 receptor subunit alpha-1; IL-22R-alpha-1; CRF2-9; ZcytoR11; IL22R	Rat	HEK293
IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Rat (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (M1-A228) with a Fc tag at the C-terminus.

HY-P77002

IL-22R alpha 1 Protein, Rat (HEK293, His) Interleukin-22 receptor subunit alpha-1; IL-22R-alpha-1; CRF2-9; ZcytoR11; IL22R	Rat	HEK293
IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Rat (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (M1-A228) with a His tag at the C-terminus.

HY-P700744

IL-22R alpha 1 Protein, Cynomolgus (HEK293, His) IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11	Cynomolgus	HEK293
IL-22R α 1 and IL-10R β together form IL20, IL22 and IL24 receptor complexes, activating different signaling pathways. Within the IL22 receptor, IL-22R α 1 binds to IL10RB and mediates IL22 signaling through the JAK/STAT and MAPK1/MAPK3/Akt pathways. IL-22R alpha 1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-22R alpha 1 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-22R alpha 1 Protein, Cynomolgus (HEK293, His) is 208 a.a., with molecular weight of 38-45 kDa.

HY-P700872

IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi) IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
Interleukin-10 Receptor Beta (IL-10Rβ) is a crucial component of the receptor complexes for interleukin-10 (IL-10), IL-22, and IL-24, playing a central role in mediating diverse signaling pathways. As part of the IL-10 receptor, IL-10Rβ forms functional heterodimers with IL-10Rα, initiating IL-10 signaling through the JAK/STAT pathways. Additionally, in collaboration with IL-22Rα1, IL-20RB, and IL-22BP, IL-10Rβ contributes to IL-22 and IL-24 signaling, activating various downstream pathways. The IL-10Rβ-containing receptor complex plays a pivotal role in modulating immune responses and maintaining cellular homeostasis. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P701062

IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi) IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P77969

IL-22R alpha 1 Protein, Mouse (HEK293, Fc) IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11	Mouse	HEK293
IL-22R α 1 and IL-10R β together form IL20, IL22 and IL24 receptor complexes, activating different signaling pathways. Within the IL22 receptor, IL-22R α 1 binds to IL10RB and mediates IL22 signaling through the JAK/STAT and MAPK1/MAPK3/Akt pathways. IL-22R alpha 1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-22R alpha 1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-22R alpha 1 Protein, Mouse (HEK293, Fc) is 213 a.a., with molecular weight of 65-68 kDa.

HY-P77423

IL-22R alpha 1 Protein, Canine (HEK293, Fc) Interleukin-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9; ZcytoR11; IL22R	Canine	HEK293
IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Canine (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (M1-The226) with a Fc tag at the C-terminus.

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