IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi)

Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

IL-22R alpha 1, in conjunction with IL-10R beta, serves as a critical component of the receptor complexes for IL20, IL22, and IL24, orchestrating diverse signaling pathways. As part of the IL22 receptor, formed by the association of IL22RA1 and IL10RB, IL-22R alpha 1 enables IL22 signaling through the JAK/STAT pathways, concurrently triggering the activation of MAPK1/MAPK3 and Akt kinases. Additionally, IL-22R alpha 1, in collaboration with IL20RB, constitutes one of the receptors for IL20 and IL24, eliciting STATs activation. The receptor complex, particularly IL-22R alpha 1, plays a pivotal role in mediating IL24's antiangiogenic effects and its inhibitory impact on endothelial cell tube formation and differentiation. In its functional state, IL-22R alpha 1 forms heterodimers with IL10RB and IL20RB, with IL22 exhibiting a higher binding affinity to the heterodimer than to IL22RA1 alone. Furthermore, the interaction between IL-22R alpha 1 and FBXW12 promotes the ubiquitination of IL22RA1, adding a regulatory layer to its function.

Human

HEK293

C-Avi;C-hFc

Q8N6P7 (H16-T228)&Q08334 (M20-S220)

58985&3588

68-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.