Siglec-2/CD22
CD22 (Siglec-2) is a B cell-restricted transmembrane lectin of the Siglec family, with an extracellular V-set domain that recognizes alpha-2,6-linked sialic acids. Its cytoplasmic tail carries ITIM and ITIM-like motifs that recruit SHP-1 and restrain B cell receptor signaling, positioning CD22 as an inhibitory co-receptor. CD22 also acts as an endocytic receptor that rapidly internalizes bound antibody, a property exploited by the antibody-drug conjugate inotuzumab ozogamicin in acute lymphoblastic leukemia. Expression begins at the pre-B cell stage and persists on mature B cells and most mature B cell malignancies. Epratuzumab, an anti-CD22 antibody, has been evaluated in systemic lupus erythematosus, and Siglec ligand blockade remains an active research area.
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Siglec-2/CD22 Recombinant Proteins (20)
Siglec-2/CD22 Protein, Human (HEK293, His)
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Cat. No.: HY-P72019
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P70560
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P72474A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His)
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Cat. No.: HY-P72474
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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CD22 Protein, Rhesus Macaque (HEK293, His)
Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P72351
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Mouse (Biotinylated, HEK293, His)
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Cat. No.: HY-P701288
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Human (512a.a, HEK293, His)
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Cat. No.: HY-P73648
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His)
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Cat. No.: HY-P77537
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Human (Biotinylated, 512a.a, HEK293, His)
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Cat. No.: HY-P77539
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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FITC-Labeled Siglec-2/CD22 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P78541
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Mouse (HEK293, Fc)
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Cat. No.: HY-P73646
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Rat (HEK293, His)
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Cat. No.: HY-P75430
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Rat (HEK293, Fc)
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Cat. No.: HY-P75431
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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CD22 Protein, Rhesus Macaque (HEK293, Fc)
Siglec-2/CD22 Protein, Canine (HEK293, His)
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Cat. No.: HY-P78641
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Rhesus macaque (HEK293, His)
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Cat. No.: HY-P700895
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Human (HEK293, Llama Fc)
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Cat. No.: HY-P704294
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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FITC-Labeled Siglec-2/CD22 Protein, Human (HEK293, His)
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Cat. No.: HY-P704302
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, Fc)
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Cat. No.: HY-P705095
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD22; B-Lymphocyte Cell Adhesion Molecule; CD22 Molecule; T-Cell Surface Antigen Leu-14; SIGLEC2; BL-CAM; Sialic Acid-Binding Ig-Like Lectin 2; Sialic Acid Binding Ig-Like Lectin 2; B-Cell Receptor CD22; CD22 Protein; CD22 Antigen; Siglec-2; SIGLEC-2
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
