1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. B Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins Siglec
  4. Siglec-2/CD22
Cat. No. Product Name / Synonyms Species Source
  • HY-P72019
    Siglec-2/CD22 Protein, Human (HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Human (HEK293, His) is 668 a.a., with molecular weight of 77-110 kDa.
  • HY-P72474
    Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; Lyb-8

    Mouse HEK293
    Siglec-2/CD22 Protein mediates B-cell B-cell interaction and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His) is the recombinant mouse-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His) is 681 a.a., with molecular weight of 100-120 kDa.
  • HY-P72474A
    Siglec-2/CD22 Protein, Mouse (HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; Lyb-8

    Mouse HEK293
    Siglec-2/CD22 is a B cell surface receptor that mediates B cell interactions and is involved in B cell localization within lymphoid tissues. It selectively binds α-2,6-linked sialic acids, including CD45, and its sialic acid recognition site may be regulated by cis interactions. Siglec-2/CD22 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Mouse (HEK293, His) is 681 a.a., with molecular weight of 95-130 kDa.
  • HY-P70559
    Siglec-2/CD22 Protein, Human (668a.a, HEK293, His)

    B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Siglec-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) is 668 a.a., with molecular weight of 100-140 kDa.
  • HY-P72351
    Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His-Avi)

    B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22; T-cell surface antigen Leu-14

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His-Avi) is 668 a.a., with molecular weight of 110-130 kDa.
  • HY-P701288
    Siglec-2/CD22 Protein, Mouse (Biotinylated, HEK293, His)

    CD22; SIGLEC2; BL-CAM; SIGLEC-2; Siglec2; SIGLEC2FLJ22814

    Mouse HEK293
    Siglec-2/CD22, a B-cell surface receptor, mediates B-cell interactions and participates in B-cell localization within lymphoid tissues. It selectively binds alpha-2,6-linked sialic acid, including CD45, with its sialic acid recognition site potentially regulated by cis interactions. In the immune response, ligand-induced tyrosine phosphorylation suggests a role in B-cell antigen receptor signaling modulation. It engages in both positive and inhibitory regulation by interacting with Src family kinases and recruiting cytoplasmic phosphatases via their SH2 domains. Interactions include LYN, SYK, PIK3R1/PIK3R2, PLCG1, SHC1, INPP5D, and GRB2 upon phosphorylation, as well as PTPN6/SHP-1 upon phosphorylation. Siglec-2/CD22 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived Siglec-2/CD22 protein, expressed by HEK293 , with His labeled tag. The total length of Siglec-2/CD22 Protein, Mouse (Biotinylated, HEK293, His) is 681 a.a., with molecular weight of 90-110 kDa.
  • HY-P70560
    Siglec-2/CD22 Protein, Human (668a.a, HEK293, Fc)

    Siglec-2; CD22; B-cell Receptor CD22

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (668a.a, HEK293, Fc) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-2/CD22 Protein, Human (668a.a, HEK293, Fc) is 668 a.a., with molecular weight of 120-150 kDa.
  • HY-P73648
    Siglec-2/CD22 Protein, Human (512a.a, HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (512a.a, HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-2/CD22 Protein, Human (512a.a, HEK293, His) is 512 a.a., with molecular weight of 90-100 kDa.
  • HY-P77537
    Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His) is 687 a.a., with molecular weight of ~76.6 KDa.
  • HY-P77539
    Siglec-2/CD22 Protein, Human (Biotinylated, 512a.a, HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2

    Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (Biotinylated, 512a.a, HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-2/CD22 Protein, Human (Biotinylated, 512a.a, HEK293, His) is 512 a.a., with molecular weight of ~58.5 KDa.
  • HY-P78541
    Siglec-2/CD22 Protein, Human (FITC, HEK293, Fc)

    CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814

    Human HEK293
    Siglec-2/CD22 Protein mediates B-cell interactions, potentially guiding B-cell localization within lymphoid tissues. Recognizing sialylated glycoproteins, especially alpha-2,6-linked sialic acid, it engages in cis interactions on the cell surface. During the immune response, ligand-induced tyrosine phosphorylation suggests its role in B-cell antigen receptor signaling. Siglec-2/CD22 acts positively through Src kinases and inhibits by recruiting phosphatases. Existing as a monomer or heterodimer, its interactions with key molecules highlight a pivotal role in complex B-cell signaling. Further research is essential for precise molecular pathways and functional consequences. Siglec-2/CD22 Protein, Human (FITC, HEK293, Fc) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293, with C-hFc labeled tag. The total length of Siglec-2/CD22 Protein, Human (FITC, HEK293, Fc) is 668 a.a., with molecular weight of 130-140 kDa.
  • HY-P73646
    Siglec-2/CD22 Protein, Mouse (690a.a, HEK293, Fc)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2

    Mouse HEK293
    Siglec-2/CD22 Protein, Mouse (690a.a, HEK293, Fc) is a Siglec of ~140 kDa with seven Ig-like domains and is expressed in a B-cell lineage-specific fashion, starting at the pre-B cell stage. CD22 is associated with membrane-bound IgM on the surface of B cells. Siglec-2 (CD22) specifically recognizes 伪2.6 sialic acid-containing glycans. Siglec-2 negatively regulates B cell antigen receptor (BCR) signaling by recruitment and activation of SH2-containing phosphatase 1 (SHP-1), which counteracts the phospharylation-mediated activation of signaling molecules by dephosphorylation, and reduces Ca2+ signaling by regulating the activity of the Ca2+ pump PMCA. Siglec-2/CD22 Protein, Mouse (690a.a, HEK293, Fc) is the recombinant mouse-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-2/CD22 Protein, Mouse (690a.a, HEK293, Fc) is 690 a.a., with molecular weight of ~125 kDa.
  • HY-P75430
    Siglec-2/CD22 Protein, Rat (692a.a, HEK293, His)

    B-cell receptor CD22; BL-CAM; CD22; T-cell surface antigen Leu-14

    Rat HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Rat (692a.a, HEK293, His) is the recombinant rat-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-2/CD22 Protein, Rat (692a.a, HEK293, His) is 692 a.a., with molecular weight of ~76.7 kDa.
  • HY-P75431
    Siglec-2/CD22 Protein, Rat (692a.a, HEK293, Fc)

    B-cell receptor CD22; BL-CAM; CD22; T-cell surface antigen Leu-14

    Rat HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Rat (692a.a, HEK293, Fc) is the recombinant rat-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-2/CD22 Protein, Rat (692a.a, HEK293, Fc) is 692 a.a., with molecular weight of ~102 kDa.
  • HY-P75626
    CD22 Protein, Rhesus Macaque (HEK293, Fc)

    B-cell receptor CD22; BL-CAM; CD22; T-cell surface antigen Leu-14

    Rhesus Macaque HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. CD22 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD22 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD22 Protein, Rhesus Macaque (HEK293, Fc) is 686 a.a., with molecular weight of ~102.1 kDa.
  • HY-P75627
    CD22 Protein, Rhesus Macaque (HEK293, His)

    B-cell receptor CD22; BL-CAM; CD22; T-cell surface antigen Leu-14

    Rhesus Macaque HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. CD22 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD22 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD22 Protein, Rhesus Macaque (HEK293, His) is 686 a.a., with molecular weight of ~76.5 kDa.
  • HY-P700895
    Siglec-2/CD22 Protein, Rhesus macaque (HEK293, His)

    CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814

    Rhesus Macaque HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-2/CD22 Protein, Rhesus macaque (HEK293, His) is 667 a.a., with molecular weight of 100-120 kDa.
Cat. No. Product Name Effect Purity