Angiotensin-converting Enzyme (ACE)
Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.
Angiotensin-converting Enzyme (ACE) Related Products (42):
| Cat. No. |
Product Name |
Effect |
Purity |
-
- HY-12403
-
| Angiotensin 1-7
|
Inhibitor
|
99.61%
|
|
Angiotensin 1-7 (Ang-(1-7)) is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
|
-
- HY-B0368
-
| Captopril
|
Inhibitor
|
98.05%
|
|
Captopril (SQ-14534) is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
|
-
- HY-B0331A
-
| Enalapril maleate
|
Inhibitor
|
99.96%
|
|
Enalapril (maleate) (MK-421 (maleate)), the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.
|
-
- HY-N2021A
-
| Phosphoramidon Disodium
|
Inhibitor
|
>98.0%
|
|
Phosphoramidon Disodium is a metalloprotease inhibitor. Phosphoramidon inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
|
-
- HY-B0130A
-
| Perindopril erbumine
|
Inhibitor
|
99.33%
|
|
Perindopril erbumine (Perindopril tert-butylamine salt) is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.
|
-
- HY-106446
-
| Rentiapril
|
Inhibitor
|
98.02%
|
|
Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity.
|
-
- HY-P0266A
-
| N-Acetyl-Ser-Asp-Lys-Pro TFA
|
|
|
|
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.
|
-
- HY-N2165
-
| Vicenin 2
|
Inhibitor
|
|
|
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium.
|
-
- HY-B0093A
-
| Benazepril hydrochloride
|
Inhibitor
|
99.85%
|
|
Benazepril hydrochloride, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure.
|
-
- HY-B0382
-
| Fosinopril sodium
|
Inhibitor
|
>98.0%
|
|
Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
|
-
- HY-18206A
-
| Lisinopril dihydrate
|
Inhibitor
|
>98.0%
|
|
Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
|
-
- HY-B0384
-
| Temocapril hydrochloride
|
Inhibitor
|
99.52%
|
|
Temocapril Hydrochloride is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
|
-
- HY-B0231
-
-
- HY-B0477
-
| Quinapril hydrochloride
|
Inhibitor
|
99.10%
|
|
Quinapril (hydrochloride) (CI-906) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.
|
-
- HY-B0592
-
| Trandolapril
|
Inhibitor
|
98.01%
|
|
Trandolapril(RU44570) is an ACE inhibitor used to treat high blood pressure.
|
-
- HY-B0279
-
| Ramipril
|
Inhibitor
|
99.81%
|
|
Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
|
-
- HY-A0043A
-
| Cilazapril monohydrate
|
Inhibitor
|
98.63%
|
|
Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
|
-
- HY-18208
-
| Omapatrilat
|
Inhibitor
|
|
|
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
|
-
- HY-B1451
-
| Imidapril hydrochloride
|
Inhibitor
|
99.95%
|
|
Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
|
-
- HY-B0378A
-
| Moexipril hydrochloride
|
Inhibitor
|
98.49%
|
|
Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure.
|
