1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-12403
    Angiotensin 1-7 Inhibitor 99.61%
    Angiotensin (1-7) inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM.
  • HY-B0368
    Captopril Inhibitor 98.05%
    Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
  • HY-B0093A
    Benazepril hydrochloride Inhibitor 99.85%
    Benazepril hydrochloride, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure.
  • HY-B0331A
    Enalapril maleate Inhibitor 99.96%
    Enalapril Maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.
  • HY-18206A
    Lisinopril dihydrate Inhibitor >98.0%
    Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
  • HY-109592
    Imidaprilate Inhibitor
    Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.
  • HY-B0130A
    Perindopril erbumine Inhibitor 99.90%
    Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.
  • HY-B0592
    Trandolapril Inhibitor 98.01%
    Trandolapril(RU44570) is an ACE inhibitor used to treat high blood pressure.
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon disodium is a metalloprotease inhibitor. Phosphoramidon inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
  • HY-B0382
    Fosinopril sodium Inhibitor >98.0%
    Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
  • HY-B0279
    Ramipril Inhibitor 99.81%
    Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
  • HY-B0477
    Quinapril hydrochloride Inhibitor 99.10%
    Quinapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.
  • HY-18208
    Omapatrilat Inhibitor
    Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
  • HY-B0384
    Temocapril hydrochloride Inhibitor 99.52%
    Temocapril Hydrochloride is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
  • HY-B0231
    Enalaprilat dihydrate Inhibitor >99.0%
    Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
  • HY-A0043A
    Cilazapril monohydrate Inhibitor 98.63%
    Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
  • HY-P0318
    Hemorphin-7 Inhibitor 99.65%
    Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE). Sequence: Tyr-Pro-Trp-Thr-Gln-Arg-Phe.
  • HY-B0130
    Perindopril Inhibitor
    Perindopril is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.
  • HY-B0331
    Enalapril Inhibitor
    Enalapril is an angiotensin converting enzyme (ACE) inhibitor.
  • HY-B0655
    Zofenopril calcium Inhibitor
    Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.
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