Signaling Pathway

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

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ACE (Angiotensin-converting enzyme) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) Inhibitors & Modulators (24)

Product Name Catalog No. Brief Description
Angiotensin 1-7

HY-12403

Angiotensin (1-7) is a endogenous peptide fragment which can induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas.

Benazepril

HY-B0093

Benazepril, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure.

Benazepril hydrochloride

HY-B0093A

Benazepril hydrochloride, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure.

Captopril

HY-B0368

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).

Cilazapril

HY-A0043

converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

Cilazapril monohydrate

HY-A0043A

Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

Enalapril

HY-B0331

Enalapril is an angiotensin converting enzyme (ACE) inhibitor.

Enalapril D5 maleate

HY-B0331AS

Enalapril D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.

Enalapril maleate

HY-B0331A

Enalapril Maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.

Enalaprilat D5

HY-B0231AS

Enalaprilat D5 is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor.

Enalaprilat D5 Sodium Salt

HY-B0231BS

Enalaprilat D5 Sodium Salt is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor.

Enalaprilat dihydrate

HY-B0231

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

Fosinopril sodium

HY-B0382

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Imidapril hydrochloride

HY-B1451

Imidapril Hydrochloride is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

Lisinopril

HY-18206

Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

Lisinopril dihydrate

HY-18206A

Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

Moexipril hydrochloride

HY-B0378A

Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure.

Perindopril

HY-B0130

Perindopril is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.

Perindopril erbumine

HY-B0130A

Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.

Quinapril hydrochloride

HY-B0477

Quinapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.