1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-12403
    Angiotensin 1-7 Inhibitor
    Angiotensin (1-7) inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM.
  • HY-B0130A
    Perindopril erbumine Inhibitor
    Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.
  • HY-A0043A
    Cilazapril monohydrate Inhibitor
    Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
  • HY-B0368
    Captopril Inhibitor
    Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
  • HY-B0384
    Temocapril hydrochloride Inhibitor
    Temocapril Hydrochloride is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
  • HY-18208
    Omapatrilat Inhibitor
    Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
  • HY-18206A
    Lisinopril dihydrate Inhibitor
    Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
  • HY-B0331A
    Enalapril maleate Inhibitor
    Enalapril Maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.
  • HY-B0231
    Enalaprilat dihydrate Inhibitor
    Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
  • HY-B0655
    Zofenopril calcium Inhibitor
    Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.
  • HY-B0378A
    Moexipril hydrochloride Inhibitor
    Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure.
  • HY-B0279
    Ramipril Inhibitor
    Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
  • HY-A0043
    Cilazapril Inhibitor
    Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
  • HY-B1451
    Imidapril hydrochloride Inhibitor
    Imidapril Hydrochloride is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
  • HY-B0231AS
    Enalaprilat D5 Inhibitor
    Enalaprilat D5 is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor.
  • HY-B0331
    Enalapril Inhibitor
    Enalapril is an angiotensin converting enzyme (ACE) inhibitor.
  • HY-B0382
    Fosinopril sodium Inhibitor
    Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
  • HY-B0592
    Trandolapril Inhibitor
    Trandolapril(RU44570) is an ACE inhibitor used to treat high blood pressure.
  • HY-B0093
    Benazepril Inhibitor
    Benazepril, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure.
  • HY-B0331AS
    Enalapril D5 maleate Inhibitor
    Enalapril D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.