1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Lisinopril

Lisinopril (Synonyms: MK-521)

Cat. No.: HY-18206
Handling Instructions

Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

For research use only. We do not sell to patients.

Lisinopril Chemical Structure

Lisinopril Chemical Structure

CAS No. : 76547-98-3

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Top Publications Citing Use of Products

Publications Citing Use of MCE Lisinopril

    Lisinopril purchased from MCE. Usage Cited in: Hum Cell. 2020 Jan 18. 

    After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.
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    Description

    Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

    IC50 & Target

    ACE.

    In Vitro

    Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2].

    Clinical Trial
    Molecular Weight

    405.49

    Formula

    C₂₁H₃₁N₃O₅

    CAS No.

    76547-98-3

    SMILES

    O=C(O)[[email protected]]1N(C([[email protected]](CCCCN)N[[email protected]](C(O)=O)CCC2=CC=CC=C2)=O)CCC1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    LisinoprilMK-521MK521MK 521Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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    Product Name:
    Lisinopril
    Cat. No.:
    HY-18206
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