Lisinopril dihydrate
Based on 6 publication(s) in Google Scholar
Lisinopri dihydrate (MK-521 dihydrate) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 83915-83-7
- Formula: C21H35N3O7
- Molecular Weight:441.52
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Lisinopril dihydrate
More- Nat Commun. 2023 Sep 21;14(1):5891. [Abstract]
- J Pharm Anal. 2025 Aug;15(8):101265. [Abstract]
- Commun Biol. 2026 Mar 31;9(1):705. [Abstract]
- Biomedicines. 2022 Jul 11;10(7):1661. [Abstract]
- Am J Physiol Renal Physiol. 2021 Aug 1;321(2):F149-F161. [Abstract]
- Hum Cell. 2020 Apr;33(2):330-336. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Biological Activity
ACE.
Lisinopri dihydrate is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 83915-83-7
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Appearance Solid
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Molecular Weight 441.52
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Formula C21H35N3O7
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Color White to off-white
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SMILES
O=C(O)[C@H]1N(C([C@H](CCCCN)N[C@H](C(O)=O)CCC2=CC=CC=C2)=O)CCC1.O.O
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Synonyms
MK-521 dihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. [Abstract]2023 Sep 21;14(1):5891. PMID: 37735515 -
J Pharm Anal
Prioritization of potential drug targets for diabetic kidney disease using integrative omics data mining and causal inference. [Abstract]2025 Aug;15(8):101265. PMID: 40979545 -
Commun Biol
2026 Mar 31;9(1):705. PMID: 41917198 -
Biomedicines
Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease. [Abstract]2022 Jul 11;10(7):1661. PMID: 35884965 -
Am J Physiol Renal Physiol
Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease. [Abstract]2021 Aug 1;321(2):F149-F161. PMID: 34180715 -
Hum Cell
Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway. [Abstract]2020 Apr;33(2):330-336. PMID: 31953678
Lisinopril dihydrate purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336. [Abstract]
HK-2 cells are treated with 0, 5, 10, 20 and 40 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay. HK-2 cells are treated with 40 μM silibinin or/and 10 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay.
Lisinopril dihydrate purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336. [Abstract]
After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.
Solvent & Solubility
H2O : 20 mg/mL (45.30 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (113.25 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (279 KB)
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SDS (418 KB)
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- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54. [Content Brief]
[2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2649 mL | 11.3245 mL | 22.6490 mL | 56.6226 mL |
| 5 mM | 0.4530 mL | 2.2649 mL | 4.5298 mL | 11.3245 mL | |
| 10 mM | 0.2265 mL | 1.1325 mL | 2.2649 mL | 5.6623 mL | |
| 15 mM | 0.1510 mL | 0.7550 mL | 1.5099 mL | 3.7748 mL | |
| 20 mM | 0.1132 mL | 0.5662 mL | 1.1325 mL | 2.8311 mL | |
| 25 mM | 0.0906 mL | 0.4530 mL | 0.9060 mL | 2.2649 mL | |
| 30 mM | 0.0755 mL | 0.3775 mL | 0.7550 mL | 1.8874 mL | |
| 40 mM | 0.0566 mL | 0.2831 mL | 0.5662 mL | 1.4156 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lisinopril dihydrate Related Classifications
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