1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Lisinopril dihydrate

Lisinopril dihydrate (Synonyms: MK-521 dihydrate)

Cat. No.: HY-18206A Purity: >98.0%
Handling Instructions

Lisinopri dihydrate (MK-521 dihydrate) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

For research use only. We do not sell to patients.

Lisinopril dihydrate Chemical Structure

Lisinopril dihydrate Chemical Structure

CAS No. : 83915-83-7

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Lisinopril dihydrate:

Top Publications Citing Use of Products

Publications Citing Use of MCE Lisinopril dihydrate

    Lisinopril dihydrate purchased from MCE. Usage Cited in: Hum Cell. 2020 Jan 18. 

    After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.
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    Description

    Lisinopri dihydrate (MK-521 dihydrate) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

    IC50 & Target

    ACE.

    In Vitro

    Lisinopri dihydrate is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2].

    Clinical Trial
    Molecular Weight

    441.52

    Formula

    C₂₁H₃₅N₃O₇

    CAS No.

    83915-83-7

    SMILES

    O=C(O)[[email protected]]1N(C([[email protected]](CCCCN)N[[email protected]](C(O)=O)CCC2=CC=CC=C2)=O)CCC1.O.O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 20 mg/mL (45.30 mM; Need ultrasonic)

    DMSO : 1 mg/mL (2.26 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2649 mL 11.3245 mL 22.6490 mL
    5 mM 0.4530 mL 2.2649 mL 4.5298 mL
    10 mM 0.2265 mL 1.1325 mL 2.2649 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    Lisinopril dihydrateMK-521 dihydrateAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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    Product Name:
    Lisinopril dihydrate
    Cat. No.:
    HY-18206A
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