1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Lisinopril dihydrate

Lisinopril dihydrate  (Synonyms: MK-521 dihydrate)

Cat. No.: HY-18206A Purity: 99.93%
COA Handling Instructions

Lisinopri dihydrate (MK-521 dihydrate) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

For research use only. We do not sell to patients.

Lisinopril dihydrate Chemical Structure

Lisinopril dihydrate Chemical Structure

CAS No. : 83915-83-7

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 77 In-stock
Solution
10 mM * 1 mL in Water USD 77 In-stock
Solid
500 mg USD 70 In-stock
1 g USD 110 In-stock
5 g USD 250 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Lisinopril dihydrate:

Top Publications Citing Use of Products

    Lisinopril dihydrate purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336.  [Abstract]

    After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.

    Lisinopril dihydrate purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336.  [Abstract]

    HK-2 cells are treated with 0, 5, 10, 20 and 40 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay. HK-2 cells are treated with 40 μM silibinin or/and 10 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay.
    • Biological Activity

    • Purity & Documentation

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    • Customer Review

    Description

    Lisinopri dihydrate (MK-521 dihydrate) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

    IC50 & Target

    ACE.

    In Vitro

    Lisinopri dihydrate is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    441.52

    Formula

    C21H35N3O7

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)[C@H]1N(C([C@H](CCCCN)N[C@H](C(O)=O)CCC2=CC=CC=C2)=O)CCC1.O.O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 33.33 mg/mL (75.49 mM; Need ultrasonic)

    DMSO : 1 mg/mL (2.26 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2649 mL 11.3245 mL 22.6490 mL
    5 mM 0.4530 mL 2.2649 mL 4.5298 mL
    10 mM 0.2265 mL 1.1325 mL 2.2649 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (113.25 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.93%

    References
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    Lisinopril dihydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Product Name:
    Lisinopril dihydrate
    Cat. No.:
    HY-18206A
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