CLM-7/CD300b

CD300b, referred to as CLM-7 in the mouse nomenclature, is a member of the CD300 family of paired immunoreceptors expressed predominantly on myeloid cells. The molecule displays a single extracellular Ig-like domain and a short cytoplasmic tail, and it transduces signals through a charged transmembrane residue that associates with the FcR gamma adapter chain. Engagement has been reported to potentiate activating pathways in macrophages and dendritic cells, complementing the inhibitory CD300A within the same receptor cluster. Physiological ligands for CD300b remain incompletely defined, and the receptor is mainly studied in the context of myeloid activation and paired-receptor evolution.