NKG2C/CD159c
NKG2C (CD159c), encoded by KLRC2, is the activating counterpart of NKG2A within the CD94 co-receptor system. Pairing with CD94, the CD94/NKG2C heterodimer recognizes HLA-E, and because NKG2C lacks an ITIM and instead carries a charged transmembrane lysine that recruits the DAP12 adaptor, engagement delivers activating signals. Following human cytomegalovirus infection, NK cells carrying NKG2C undergo adaptive-like clonal expansion and persist as long-lived memory NK cells, a phenomenon shaped by HLA-E genetics and DAP12 variants. This adaptive NK compartment is studied in viral immunity and is being harnessed in NK cell-based immunotherapy approaches.
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NKG2C/CD159c Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
