1. Membrane Transporter/Ion Channel
  2. Chloride Channel

Chloride Channel

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Chloride Channel Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-12693
    R(+)-IAA-94 Inhibitor 99.80%
    R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.
  • HY-B0493
    Niflumic acid Inhibitor
    Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
  • HY-P0173
    Chlorotoxin Inhibitor
    Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity; inhibits the migration of U251MG cell with an IC50 of 600 nM.
  • HY-B0679
    Lubiprostone Activator
    Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.