356102-14-2
356102-14-2
Chemical Structure
Ani9
- CAS No.: 356102-14-2
- Formula:C17H17ClN2O3
- Molecular Weight:332.78
IUPAC Name: (E)-2-(4-chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
InChIKey: KDALDZRKOBJXIE-VXLYETTFSA-N
SMILES: O=C(COC1=CC=C(C=C1C)Cl)N/N=C/C2=CC=CC=C2OC
Biological Activity: Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ani9 | 99.12% | Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors. | ||||||||||||||||||||
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References
- [1]. Seo Y, et al. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One. 2016 May 24;11(5):e0155771. [Content Brief]
- [2]. Seo Y, et al. Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors. Eur J Med Chem. 2018 Dec 5;160:245-255. [Content Brief]
- [3]. Naoki Kawata, et al. Increased TMEM16A-Mediated Ca2+-Activated Cl− Currents in Portal Vein Smooth Muscle Cells of Caveolin 1-Deficient Mice. Biol. Pharm. Bull. 45, 1692–1698 (2022).
Keywords
