Tumors

DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research.

DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG2000-iRGD can be used for agent delivery.

DSPE-PEG2000-cRGD is a PEG compound which composed of DSPE and an αvβ3 targeting peptide (cRGD). cRGD peptide can specifically bind to αvβ3 on the surface of many cancer cells and neovascular cells. DSPE-PEG2000-cRGD can be used for drug delivery.

DSPE-PEG2000-GE11 is a nanocarrier component composed of DSPE and the EGFR-targeting peptide (GE11). DSPE-PEG2000-GE11 specifically binds to EGFR and mediates receptor-mediated endocytosis of micellar drug carriers. DSPE-PEG2000-GE11 can be used for drug delivery.

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells.

DSPE-PEG2000-VHPKQHRGGSKGC is a targeted modified phospholipid-polyethylene glycol conjugate covalently coupled to DSPE, PEG, and the vascular-targeting peptide VHPKQHRGGSKGC. DSPE-PEG2000-VHPKQHRGGSKGC can be used for research on tumor vascular imaging and vascular-targeted drug delivery.

DSPE-PEG2000-CREKA is a PEG compound which composed of DSPE and a fibrin-targeting peptide (CREKA). CREKA peptide can be used to target tumor cells and tumor vasculature, exhibiting antitumor activity. DSPE-PEG2000-CREKA can be used for drug delivery.

DSPE-PEG3400-ANG is a PEG compound which composed of DSPE and a dual-targeting ligand (Angiopep-2, ANG). ANG exhibits high LRP1 binding efficiency and has been used for glioma-targeting delivery. DSPE-PEG3400-ANG can be used for drug delivery.

DSPE-PEG2000-NGR is a PEG compound which composed of DSPE and an Asn-Gly-Arg (NGR) peptide. NGR peptide can target tumor vascular antigen CD13. DSPE-PEG2000-NGR can be used for drug delivery.

DSPE-PEG2000-YIGSR is a PEG compound which composed of DSPE and a biomimetic peptide YIGSR. YIGSR interacts with the 67 kDa laminin binding protein (LBP) and promotes adhesion and spreading of a large number of cell types including endothelial cells, fibroblasts and smooth muscle cells. DSPE-PEG2000-YIGSR can be used for drug delivery.

DMG-PEG2000-PTP (DMG-PEG2000-Mal-Cys-KTLLPTP) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and a PTP (HY-P11850) peptide as a terminal targeting/functional ligand. DMG-PEG2000-PTP can be used in research on targeted drug delivery for pancreatic cancer.

DMG-PEG2000-BR2 (DMG-PEG2000-Mal-Cys-RAGLQFPVGRLLRRLLR) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and a BR2 peptide as a terminal targeting/functional ligand. DMG-PEG2000-BR2 can be used in research on targeted drug delivery for breast cancer.

DMG-PEG2000-APRPG (DMG-PEG2000-Mal-Cys-APRPG) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an APRPG peptide as a terminal targeting/functional ligand. DMG-PEG2000-APRPG can be used in research on tumor angiogenesis-targeted drug delivery.

DSG-PEG2000-TH (DSG-PEG2000-Mal-Cys-TH) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and a TH peptide as a terminal targeting/functional ligand. DSG-PEG2000-TH can be used in studies of tumor microenvironment-responsive drug delivery.

DMG-PEG2000-ESBP (DMG-PEG2000-Mal-Cys-DITWDQLWDLMK) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an ESBP peptide as a terminal targeting/functional ligand. DMG-PEG2000-ESBP can be used in research such as targeted drug delivery for inflammation.

DSG-PEG2000-YIGSR (DSG-PEG2000-Mal-Cys-YIGSR) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and a YIGSR (HY-P0132) peptide as a terminal targeting/functional ligand. DSG-PEG2000-YIGSR can be used in research such as tumor-targeted drug delivery.

DSG-PEG2000-DHLASLWWGTEL (DSG-PEG2000-Mal-Cys-DHLASLWWGTEL) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and the DHLASLWWGTEL peptide as a terminal targeting/functional ligand. DSG-PEG2000-DHLASLWWGTEL can be used in research on targeted drug delivery for hepatocellular carcinoma.

DSG-PEG2000-F3 (DSG-PEG2000-Mal-Cys-KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and an F3 (HY-P10997) peptide as a terminal targeting/functional ligand. DSG-PEG2000-F3 can be used in research such as tumor-targeted drug delivery.

DMG-PEG2000-NGR (DMG-PEG2000-Mal-Cys-NGR) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an NGR (HY-P1043) peptide as a terminal targeting/functional ligand. DMG-PEG2000-NGR can be used for tumor angiogenesis-targeted drug delivery.

DSG-PEG2000-GRGDS (DSG-PEG2000-Mal-Cys-GRGDS) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and a Gly-Arg-Gly-Asp-Ser (GRGDS) (HY-P0295) peptide as a terminal targeting/functional ligand. DSG-PEG2000-GRGDS can be used in research on tumor-targeted drug delivery.