DSPE-PEG2000-iRGD

Name: DSPE-PEG2000-iRGD
Brand: MedChemExpress
SKU: HY-172494
Rating: 4.5 (1 reviews)

Cat. No.: HY-172494 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
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DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG2000-iRGD can be used for agent delivery.

For research use only. We do not sell to patients.

DSPE-PEG2000-iRGD Chemical Structure

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

αvβ1

αvβ3

αvβ5

αvβ6

αvβ8

In Vitro

DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties^[1].
M-SAL-iRGD (iRGD-conjugated DSPE-PEG2000 nanomicelles) constructed with DSPE-PEG2000-iRGD are used for targeted delivery of Salinomycin (HY-15597) to intervene in liver cancer cells and cancer stem cells^[2].
iRGD-LP-CUR-PIP, constructed with DSPE-PEG2000-iRGD, is a tumor-penetrating peptide liposome that exhibits antitumor effects, mainly manifested in a significant reduction in tumor volume and an increase in body weight and spleen index^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2000 (Average)

Appearance

Solid

Color

White to off-white

SMILES

[CRGDKGPDC (Disulfide bridge:Cys1-Cys9)]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 5.56 mg/mL (Need ultrasonic)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.0%

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Data Sheet (273 KB) SDS (251 KB)

COA (248 KB) HNMR (263 KB) MS (348 KB)

Handling Instructions (2659 KB)

References

[1]. Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74. [Content Brief]

[2]. Mao X, et al. iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells. Nanomedicine (Lond). 2015;10(17):2677-95. [Content Brief]

[3]. Wang Y, et al. The Antitumour Activity of a Curcumin and Piperine Loaded iRGD-Modified Liposome: In Vitro and In Vivo Evaluation. Molecules. 2023 Sep 9;28(18):6532. [Content Brief]