α4β7

α4β7 integrin is a lymphocyte adhesion receptor that mediates binding to MAdCAM-1 and supports selective lymphocyte homing to gut-associated lymphoid tissue[1]. Mechanistically, α4β7 enables rolling adhesion under flow and ligand-dependent conformational activation, linking integrin structure to intestinal immune-cell trafficking[2]. In disease models, T cell-associated α4β7, but not α4β1, drives chronic colitis, while antibody-secreting cells depend on α4β7/MAdCAM-1 for intestinal recruitment and microbiota control[3][4]. Compared with related isoforms, α4β7 chiefly supports intestinal homing through MAdCAM-1, whereas α4β1 associates with VCAM-1 and αEβ7 supports epithelial retention through E-cadherin[2][4]. For experimental and translational applications, vedolizumab selectively antagonizes α4β7 and showed induction and maintenance efficacy in ulcerative colitis and Crohn’s disease trials[5][6].
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