1. Cytoskeleton
  2. Integrin

Firategrast (Synonyms: SB 683699)

Cat. No.: HY-14951 Purity: 99.66%
Handling Instructions

Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist.

For research use only. We do not sell to patients.

Firategrast Chemical Structure

Firategrast Chemical Structure

CAS No. : 402567-16-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 304 In-stock
Estimated Time of Arrival: December 31
5 mg USD 276 In-stock
Estimated Time of Arrival: December 31
10 mg USD 426 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1008 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist.

IC50 & Target

α4β1/α4β7[1]

In Vitro

Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS)[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (200.20 mM)

Ethanol : ≥ 50 mg/mL (100.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0020 mL 10.0100 mL 20.0200 mL
5 mM 0.4004 mL 2.0020 mL 4.0040 mL
10 mM 0.2002 mL 1.0010 mL 2.0020 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  1% SBE-beta-CD

    Solubility: 0.2 mg/mL (0.40 mM); Clear solution; Need ultrasonic and warming

References
Molecular Weight

499.50

Formula

C₂₇H₂₇F₂NO₆

CAS No.

402567-16-2

SMILES

O=C(O)[[email protected]@H](NC(C1=C(F)C=CC=C1F)=O)CC2=CC=C(C3=C(OC)C=C(COCC)C=C3OC)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.66%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Firategrast
Cat. No.:
HY-14951
Quantity:

Firategrast

Cat. No.: HY-14951