2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Superfamily Ligands
  6. OX40 Ligand

OX40 Ligand

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OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa[1]. Human OX40 Ligand shares <70% aa sequence identity with mouse, rat and rabbit. Mouse OX40 Ligand shares 81.31% aa sequence identity with rat. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand is expressed on antigen-expressing cells, such as B cells, dendritic cells (DCs), and macrophages, and airway smooth muscle cells[2]. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs.[1][3]. The upregulation of OX40 and OX40L may induce abnormal activation of Tfh cells and excessive production of autoantibodies, which leads to autoimmune disease[1].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70622
    OX40 Ligand/TNFSF4 Protein, Human (HEK293, His)

    Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1

    		Human HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Human (HEK293, His) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal 6*His tag, which is produced in HEK293.
  • HY-P72497
    OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, His)

    Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4

    		Mouse HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, His) is a recombinant mouse OX40 Ligand (S51-L198) with N-terminal 8*His tag, which is produced in HEK293.
  • HY-P700225AF
    Animal-Free OX40 Ligand/TNFSF4 Protein, Mouse (His)

    Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4

    		Mouse E. coli
    The OX40 ligand/TNFSF4 protein is a cytokine that selectively binds to TNFRSF4 and serves as a key costimulator for T cell proliferation and cytokine production. As a homotrimer, this ligand plays a key role in modulating immune responses, particularly in enhancing T cell activation and function. Animal-Free OX40 Ligand/TNFSF4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeOX40 Ligand/TNFSF4 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free OX40 Ligand/TNFSF4 Protein, Mouse (His) is 148 a.a., with molecular weight of ~17.68 kDa.
  • HY-P72498
    OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, His)

    Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4

    		Cynomolgus HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus OX40 Ligand (Q51-L183) with N-terminal 8*His tag, which is produced in HEK293.
  • HY-P74660
    OX40 Ligand/TNFSF4 Protein, Rat (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Rat HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Rat (HEK293, Fc) is a recombinant rat OX40 Ligand (V20-P210) with C-terminal hFc tag, which is produced in HEK293.
  • HY-P78504
    OX40 Ligand/TNFSF4 Protein, Human (HEK293, His-Flag)

    OX40L; OX-40L; OX4OL; CD252; TNFSF4; OX40 Ligand; CD134 ligand; CD134L;  TXGP1; Glycoprotein Gp34

    		Human HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Human (HEK293, His-Flag) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal His and Flag tag, which is produced in HEK293.
  • HY-P77458
    OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Human HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal hFc tag, which is produced in HEK293.
  • HY-P77459
    OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Mouse HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, Fc) is a recombinant mouse OX40 Ligand (Q49-L198) with N-terminal mFc tag, which is produced in HEK293.
  • HY-P77460
    OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, rFc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Mouse HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, rFc) is a recombinant mouse OX40 Ligand (Q49-L198) with N-terminal rFc tag, which is produced in HEK293.
  • HY-P77457
    OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Cynomolgus HEK293
    The OX40 Ligand/TNFSF4 Protein, a vital member of the tumor necrosis factor family, is crucial for regulating immune responses and inflammation. Its study enhances understanding of immune modulation, offering potential applications in immunotherapy and autoimmune disease management. OX40 Ligand/TNFSF4's classification within the tumor necrosis factor family underscores its unique contributions to T cell activation and co-stimulation. Further exploration promises to enhance our knowledge of its role in both normal immune function and pathological conditions. OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293, with N-mFc labeled tag. The total length of OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is 133 a.a., with molecular weight of ~48 kDa.
  • HY-P700500
    OX40 Ligand/TNFSF4 Protein, Rabbit (HEK293, hFc)

    Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1

    		Rabbit HEK293
    OX40 Ligand/TNFSF4 Protein, a cytokine, binds TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. As a homotrimer, its pivotal interaction with TNFRSF4 enhances immune response by activating and expanding T-cells. This engagement contributes to intricate regulation, making OX40 Ligand a key mediator in modulating T-cell functions for effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Rabbit (HEK293, hFc) is the recombinant Rabbit-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of OX40 Ligand/TNFSF4 Protein, Rabbit (HEK293, hFc) is 143 a.a., with molecular weight of 44.9 kDa.
  • HY-P700501
    OX40 Ligand/TNFSF4 Protein, Rabbit (P. pastoris, His-Myc)

    Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1

    		Rabbit P. pastoris
    OX40 Ligand/TNFSF4 Protein, a cytokine, binds TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. As a homotrimer, its pivotal interaction with TNFRSF4 enhances immune response by activating and expanding T-cells. This engagement contributes to intricate regulation, making OX40 Ligand a key mediator in modulating T-cell functions for effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Rabbit (P. pastoris, His-Myc) is the recombinant Rabbit-derived OX40 Ligand/TNFSF4 protein, expressed by P. pastoris , with C-6*His, Myc labeled tag. The total length of OX40 Ligand/TNFSF4 Protein, Rabbit (P. pastoris, His-Myc) is 143 a.a., with molecular weight of 19.8 kDa.
Cat. No. Product Name Effect Purity