2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Superfamily Ligands
  6. OX40 Ligand

OX40 Ligand

OX40 Ligand

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OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa[1]. Human OX40 Ligand shares <70% aa sequence identity with mouse, rat and rabbit. Mouse OX40 Ligand shares 81.31% aa sequence identity with rat. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand is expressed on antigen-expressing cells, such as B cells, dendritic cells (DCs), and macrophages, and airway smooth muscle cells[2]. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs.[1][3]. The upregulation of OX40 and OX40L may induce abnormal activation of Tfh cells and excessive production of autoantibodies, which leads to autoimmune disease[1].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78504
    OX40 Ligand/TNFSF4 Protein, Human (HEK293, His-Flag)

    OX40L; OX-40L; OX4OL; CD252; TNFSF4; OX40 Ligand; CD134 ligand; CD134L;  TXGP1; Glycoprotein Gp34

    		Human HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Human (HEK293, His-Flag) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal His and Flag tag, which is produced in HEK293.
  • HY-P70622
    OX40 Ligand/TNFSF4 Protein, Human (HEK293, His)

    Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1

    		Human HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Human (HEK293, His) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal 6*His tag, which is produced in HEK293.
  • HY-P72497
    OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, His)

    Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4

    		Mouse HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, His) is a recombinant mouse OX40 Ligand (S51-L198) with N-terminal 8*His tag, which is produced in HEK293.
  • HY-P77458
    OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Human HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal hFc tag, which is produced in HEK293.
  • HY-P77459
    OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Mouse HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, Fc) is a recombinant mouse OX40 Ligand (Q49-L198) with N-terminal mFc tag, which is produced in HEK293.
  • HY-P77460
    OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, rFc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Mouse HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, rFc) is a recombinant mouse OX40 Ligand (Q49-L198) with N-terminal rFc tag, which is produced in HEK293.
  • HY-P72498
    OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, His)

    Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4

    		Cynomolgus HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus OX40 Ligand (Q51-L183) with N-terminal 8*His tag, which is produced in HEK293.
  • HY-P74660
    OX40 Ligand/TNFSF4 Protein, Rat (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Rat HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Rat (HEK293, Fc) is a recombinant rat OX40 Ligand (V20-P210) with C-terminal hFc tag, which is produced in HEK293.
  • HY-P77457
    OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc)

    CD134L; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40L; TXGP1

    		Cynomolgus HEK293
    OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus OX40 Ligand (Q51-L183) with N-terminal mFc tag, which is produced in HEK293.
  • HY-P700225AF
    Animal-Free OX40 Ligand/TNFSF4 Protein, Mouse (His)

    Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4

    		Mouse E. coli
Cat. No. Product Name Effect Purity