2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Protease Inhibitors
  5. Serpin (Protease Inhibitor)

Serpin (Protease Inhibitor)

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Serpin (Protease Inhibitor)

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Serpins (serine proteinase inhibitors) are a superfamily of evolutionarily conserved, structurally homologous proteins that antagonize the activity of serine proteases and involved in many critical biological processes like blood coagulation, fibrinolysis

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72831
    Antithrombin III/Serpin C1 Protein, Human (432a.a, HEK293, His)

    Antithrombin-III; ATIII; Serpin C1; SERPINC1; AT3

    		Human HEK293
    Antithrombin III/Serpin C1 protein, the main plasma serine protease inhibitor, regulates the blood coagulation cascade. It inhibits thrombin, matriptase-3/TMPRSS7, and factors IXa, Xa, and XIa, with enhanced potency in the presence of heparin. Furthermore, it forms a protease-inhibiting heterodimer with TMPRSS7. Antithrombin III/Serpin C1 Protein, Human (432a.a, HEK293, His) is the recombinant human-derived Antithrombin III/Serpin C1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Antithrombin III/Serpin C1 Protein, Human (432a.a, HEK293, His) is 432 a.a., with molecular weight of 55-60 kDa.
  • HY-P73372
    Serpin F1 Protein, Mouse (HEK293, His)

    Pigment epithelium-derived factor; Pedf; Sdf3; Caspin; Serpin F1

    		Mouse HEK293
    Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects. Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity. Serpin F1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin F1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin F1 Protein, Mouse (HEK293, His) is 398 a.a., with molecular weight of 60-65 kDa.
  • HY-P73412
    Serpin A3 Protein, Human (HEK293, His)

    Alpha-1-Antichymotrypsin; ACT; Serpin A3; SERPINA3; AACT

    		Human HEK293
    Serpin A3 protein is a serine protease inhibitor on chromosome 14 that affects protease targeting through tissue-specific polymorphisms. Sequence variants are associated with Alzheimer's disease, while deficiencies are associated with liver disease. Serpin A3 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A3 Protein, Human (HEK293, His) is 398 a.a., with molecular weight of ~50-70 kDa.
  • HY-P73526
    Serpin G1 Protein, Human (500a.a, HEK293, His)

    C1IN; C1INH; SERPING1; Serpin G1; Plasma protease C1 inhibitor

    		Human HEK293
    Serpin G1, also known as C1-inhibitor, controls C1 complex activation by forming a proteolytically inactive complex with C1r or C1s proteases. Its interactions regulate physiological pathways like complement activation, blood coagulation, fibrinolysis, and kinin generation. As a potent inhibitor of FXIIa, chymotrypsin, and kallikrein, Serpin G1 binds to E. coli stcE, protecting against complement-mediated lysis, and engages with MASP1, showcasing its intricate involvement in various cellular processes. Serpin G1 Protein, Human (500a.a, HEK293, His) is the recombinant human-derived Serpin G1 protein, expressed by HEK293, with C-10*His labeled tag. The total length of Serpin G1 Protein, Human (500a.a, HEK293, His) is 478 a.a., with molecular weight of ~110 kDa.
  • HY-P76720
    Alpha-2-Antiplasmin/Serpin F2 Protein, Human (HEK293, His)

    Alpha-2-AP; Alpha-2-plasmin inhibitor; Alpha-2-PI; AAP; PLI

    		Human HEK293
    Alpha-2-Antiplasmin/Serpin F2 Protein, a serine protease inhibitor, primarily targets plasmin and trypsin, also inactivating matriptase-3/TMPRSS7 and chymotrypsin. It can form a heterodimer with TMPRSS7, enhancing its protease inhibitory activity. Alpha-2-Antiplasmin/Serpin F2 Protein, Human (HEK293, His) is the recombinant human-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Alpha-2-Antiplasmin/Serpin F2 Protein, Human (HEK293, His) is 491 a.a., with molecular weight of ~70 kDa.
  • HY-P72044
    TMPRSS2 Protein, Human (R255Q, HEK293, His)

    Serine protease 10

    		Human HEK293
    The TMPRSS2 protein is a plasma membrane-anchored serine protease that plays critical roles in prostate physiology, cancer metastasis, pain modulation, and viral infection. Its lytic activity affects proteolytic cascades involved in prostate function, and androgen-induced activation contributes to cancer progression. TMPRSS2 Protein, Human (R255Q, HEK293, His) is the recombinant human-derived TMPRSS2 protein, expressed by HEK293 , with N-10*His labeled tag and R255Q, , , , mutation. The total length of TMPRSS2 Protein, Human (R255Q, HEK293, His) is 387 a.a., with molecular weight of ~46.71 kDa.
  • HY-P71077
    Serpin E1 Protein, Human (HEK293, His)

    Plasminogen Activator Inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; SERPINE1; PAI1; PLANH1

    		Human HEK293
    Serpin E1 is a serine protease inhibitor that regulates various cellular processes by inhibiting TMPRSS7, tissue-type plasminogen activator (PLAT), and urokinase-type plasminogen activator (PLAU). During fibrinolysis, it downregulates PLAT to control thrombus degradation and acts as a PLAU inhibitor to regulate cell adhesion. Serpin E1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E1 Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~44-51 kDa.
  • HY-P7054
    PEDF Protein, Human

    rHuPEDF; SerpinF1; EPC-1

    		Human E. coli
    PEDF Protein, Human is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family.
  • HY-P70498
    Serpin F1 Protein, Human (HEK293, His)

    Pigment Epithelium-Derived Factor; PEDF; Cell Proliferation-Inducing Gene 35 Protein; EPC-1; Serpin F1; SERPINF1; PEDF

    		Human HEK293
    Serpin F1 protein, a neurotrophic factor, crucially promotes extensive neuronal differentiation in retinoblastoma cells and serves as a potent inhibitor of angiogenesis. Unlike active serpins, Serpin F1 does not undergo the typical S (stressed) to R (relaxed) conformational transition, lacking serine protease inhibitory activity. It also interacts with PNPLA2, enhancing the phospholipase A2 activity of PNPLA2. Serpin F1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin F1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin F1 Protein, Human (HEK293, His) is 399 a.a., with molecular weight of ~50.0 kDa.
  • HY-P71300
    Vaspin Protein, Human (HEK293, His)

    Serpin A12; OL-64; Visceral adipose tissue-derived serine protease inhibitor; Vaspin; Visceral adipose-specific serpin; SERPINA12

    		Human HEK293
    Vaspin is an adipokine that regulates adipogenesis, metabolism, and inflammation by binding to the chemokine receptors CMKLR1 and CMKLR2. It mainly regulates adipocyte differentiation and affects lipid and glucose metabolism genes. Vaspin Protein, Human (HEK293, His) is the recombinant human-derived Vaspin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Vaspin Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-60 kDa.
  • HY-P71298
    Serpin H1 Protein, Human (HEK293, His)

    Serpin H1; 47 kDa Heat Shock Protein; Arsenic-Transactivated Protein 3; AsTP3; Cell Proliferation-Inducing Gene 14 Protein; Collagen-Binding Protein; Colligin; Rheumatoid Arthritis-Related Antigen RA-A47; SERPINH1; CBP1; CBP2; HSP47; SERPINH2

    		Human HEK293
    Serpin H1 protein exhibits a specific affinity for collagen, indicating its role as a chaperone in the biosynthetic pathway of collagen. This suggests its potential contribution to collagen synthesis, emphasizing its importance in maintaining tissue integrity and modulating cellular responses related to collagen metabolism. Serpin H1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin H1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin H1 Protein, Human (HEK293, His) is 400 a.a., with molecular weight of ~51.0 kDa.
  • HY-P7270
    Neuroserpin Protein, Human (CHO)

    rHuNeuroserpin; Peptidase inhibitor 12; Serpin I1; SERPINI1

    		Human CHO
    Neuroserpin Protein, Human (CHO) is a member of the serpin family of serine protease inhibitors, playing an important role in synaptic plasticity and memory formation in the hippocampus.
  • HY-P77693
    TMPRSS1/HPN Protein, Human (HEK293, His)

    Hpxn; FLJ56652; Hemopexin; HPX; HX; Hepsin; HPN; TMPRSS1

    		Human HEK293
    TMPRSS1/HPN is a serine protease that cleaves extracellular substrates and is involved in the proteolytic processing of growth factors such as HGF and MST1/HGFL. In addition to growth factor regulation, TMPRSS1/HPN is also critical for cell growth and morphology maintenance. TMPRSS1/HPN Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS1/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of TMPRSS1/HPN Protein, Human (HEK293, His) is 373 a.a., with molecular weight of 18-22 kDa&30 kDa.
  • HY-P70498A
    Serpin F1 Protein, Human (HEK293, N-His)

    Pigment Epithelium-Derived Factor; PEDF; Cell Proliferation-Inducing Gene 35 Protein; EPC-1; Serpin F1; SERPINF1; PEDF

    		Human HEK293
    Serpin F1 protein, a neurotrophic factor, crucially promotes extensive neuronal differentiation in retinoblastoma cells and serves as a potent inhibitor of angiogenesis. Unlike active serpins, Serpin F1 does not undergo the typical S (stressed) to R (relaxed) conformational transition, lacking serine protease inhibitory activity. It also interacts with PNPLA2, enhancing the phospholipase A2 activity of PNPLA2. Serpin F1 Protein, Human (HEK293, N-His) is the recombinant human-derived Serpin F1 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of Serpin F1 Protein, Human (HEK293, N-His) is 399 a.a., with molecular weight of ~49.37 kDa.
  • HY-P72043
    TMPRSS2 Protein, Human (P.pastoris, His)

    Serine protease 10; PRSS10;

    		Human P. pastoris
    The TMPRSS2 protein is a plasma membrane-anchored serine protease that plays critical roles in prostate physiology, cancer metastasis, pain modulation, and viral infection. Its lytic activity affects proteolytic cascades involved in prostate function, and androgen-induced activation contributes to cancer progression. TMPRSS2 Protein, Human (P.pastoris, His) is the recombinant human-derived TMPRSS2 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of TMPRSS2 Protein, Human (P.pastoris, His) is 387 a.a., with molecular weight of ~45 kDa.
  • HY-P71292
    Serpin A10 Protein, Human (HEK293, His)

    Protein Z-Dependent Protease Inhibitor; PZ-Fependent Protease Inhibitor; PZI; Serpin A10; SERPINA10; ZPI

    		Human HEK293
    Serpin A10 protein inhibits coagulation proteases, such as factor Xa, in the presence of PROZ, calcium, and phospholipids. It can also inhibit factor XIa without cofactors. Serpin A10 interacts with PROZ to exert its inhibitory effects on these coagulation factors. Serpin A10 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A10 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A10 Protein, Human (HEK293, His) is 423 a.a., with molecular weight of 55-80 kDa.
  • HY-P71295
    Alpha-2-Antiplasmin/Serpin F2 Protein, Mouse (HEK293, His)

    Alpha-2-antiplasmin; Alpha-2-AP; Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2; Serpinf2

    		Mouse HEK293
    Alpha-2-Antiplasmin/Serpin F2 Protein, a serine protease inhibitor, targets plasmin and trypsin, also inhibiting matriptase-3/TMPRSS7 and chymotrypsin. It forms a heterodimer with TMPRSS7, enhancing its protease inhibiting activity. Alpha-2-Antiplasmin/Serpin F2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Alpha-2-Antiplasmin/Serpin F2 Protein, Mouse (HEK293, His) is 464 a.a., with molecular weight of 70-85 kDa.
  • HY-P71054
    Serpin A3 Protein, Human (K267R, HEK293, His)

    Alpha-1-Antichymotrypsin; ACT; Cell Growth-Inhibiting Gene 24/25 Protein; Serpin A3; SERPINA3; AACT

    		Human HEK293
    Serpin A3 Proteinas, with unclear physiological function, inhibits neutrophil cathepsin G and mast cell chymase, involved in angiotensin-1 to angiotensin-2 conversion. Serpin A3 also interacts with DNAJC1. Serpin A3 Protein, Human (K267R, HEK293, His) is the recombinant human-derived Serpin A3 protein, expressed by HEK293 , with C-6*His labeled tag and K267R mutation. The total length of Serpin A3 Protein, Human (K267R, HEK293, His) is 400 a.a., with molecular weight of 56-80 kDa.
  • HY-P71079
    Serpin A7 Protein, Human (HEK293, His)

    Thyroxine-Binding Globulin; Serpin A7; T4-Binding Globulin; SERPINA7; TBG

    		Human HEK293
    Serpin A7, or thyroxine-binding globulin (TBG), acts as a glycoprotein carrier for thyroid hormones, specifically binding and transporting thyroxine (T4) and triiodothyronine (T3). TBG regulates the availability and distribution of thyroid hormones critical for physiological processes like metabolism and growth. Mutations in the SERPINA7 gene can affect TBG function, influencing thyroid hormone levels. Serpin A7 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A7 Protein, Human (HEK293, His) is 395 a.a., with molecular weight of 55-65 kDa.
  • HY-P71133
    Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His)

    Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; Serpin E1; Mr1; Pai1; Planh1;

    		Mouse HEK293
    Serpin E1 Protein, a serine protease inhibitor, regulates TMPRSS7 and is a primary inhibitor for tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). It crucially down-regulates fibrinolysis, controlling blood clot degradation. As a PLAU inhibitor, Serpin E1 regulates cell adhesion and spreading, contributing to keratinocyte migration in cutaneous injury repair. Beyond protease inhibition, it regulates cell migration, influencing senescence, alveolar type 2 cells' senescence in the lung, cementogenic differentiation in periodontal ligament stem cells, and odontoblast differentiation in odontogenesis. Serpin E1 forms a heterodimer with TMPRSS7, interacts with proteins like VTN, PPP1CB, SORL1, LRP1, and PLAUR, emphasizing its multifaceted regulatory role. Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) is the recombinant mouse-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag and N172S, R253G mutation. The total length of Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) is 380 a.a., with molecular weight of ~48.54 kDa.
Cat. No. Product Name Effect Purity