Serpin B4
Serpin B4, also known as squamous cell carcinoma antigen 2 (SCCA2), is the closest paralog of Serpin B3/SCCA1 and likewise functions as an intracellular, signal peptide-free serpin of squamous epithelia. Its reactive center loop preferentially inhibits chymotrypsin-like serine proteases, including cathepsin G and chymase, complementing the broader cysteine protease profile of SCCA1. Serpin B4 is strongly induced in differentiating keratinocytes, in atopic and psoriatic skin, and in SCCA-positive carcinomas of cervix, lung, and head and neck, where serum SCCA serves as a clinical tumor marker. Recombinant Serpin B4 is used in SCCA immunoassays, epithelial cytoprotection studies, and protease selectivity comparisons with Serpin B3.
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Serpin B4 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
