E1 Enzymes
Ubiquitin or ubiquitin-like proteins (UBLs) carboxyl termini are attached to other proteins, or in some cases lipids, generally through E1-E2-E3 multienzyme cascades. The E1 activating enzymes (ubiquitin-activating enzyme) serve to activate ubiquitin/UBLs through C-terminal adenylation and thiol transfer and to coordinate the utilization of ubiquitin/UBLs in specific downstream pathways by charging cognate E2 enzymes, which then interact with the downstream ubiquitylation machinery to coordinate modification of the target. In humans, there are eight E1 activating enzymes are known so far, including canonical (UBA1, UBA6, UBA7, SAE, and NAE) and non-canonical (UBA4, UBA5, and ATG7) E1 enzymes.
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E1 Enzymes Recombinant Proteins (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
