1. Signaling Pathways
  2. Immunology/Inflammation
  3. Complement System

Complement System

The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system. Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.

Complement System Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-B0579
    Cyclosporin A Inhibitor >98.0%
    Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
  • HY-14648
    Dexamethasone Inhibitor 99.86%
    Dexamethasone is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18L expression on monocytes.
  • HY-101502A
    SB290157 trifluoroacetate Antagonist 99.87%
    SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.
  • HY-17627
    Avacopan Inhibitor 99.53%
    Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC50 of 0.1 nM.
  • HY-110136A
    PMX 205 Trifluoroacetate Antagonist 98.89%
    PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR; CD88) antagonist.
  • HY-117930
    Danicopan Inhibitor 99.91%
    Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
  • HY-P1505A
    C3a (70-77) TFA 98.64%
    C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
  • HY-128342
    Complement C5-IN-1 Inhibitor
    Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1 interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77 µM.
  • HY-P1036
    Compstatin Inhibitor 98.36%
    Compstatin is a 13-residue cyclic peptide and a potent inhibitor of the complement system, and has species specificity.
  • HY-15701
    Leukadherin-1 Agonist >98.0%
    Leukadherin-1 is a specific agonist of CR3 and the leukocyte surface integrin CD11b/CD18.
  • HY-16992A
    W-54011 Antagonist >98.0%
    W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist.
  • HY-50875
    BCX 1470 methanesulfonate Inhibitor 99.43%
    BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.
  • HY-110136
    PMX 205 Antagonist
    PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.
  • HY-50874
    BCX 1470 Inhibitor
    BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.
  • HY-127105
    LNP023 Inhibitor
    LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM).
  • HY-128570
    FD-IN-1 Inhibitor
    FD-IN-1 (Compound 12) is a factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5µM, respectively.
  • HY-P1505
    C3a 70-77
    C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
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