Dextran sulfate sodium salt (MW 5000)
Based on 5 publication(s) in Google Scholar
Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR).
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 9011-18-1
- Molecular Weight:5000(Average)
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-116282C
Dextran sulfate sodium salt (MW 35000-45000)
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HY-116282B
Dextran sulfate sodium salt (MW 16000-24000)
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HY-116282D
Dextran sulfate sodium salt (MW 450000-550000)
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HY-116282I
Dextran sulfate sodium salt (MW>500000)
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HY-111375
Azoxymethane
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HY-116282A
Dextran sulfate sodium salt (MW 4500-5500)
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HY-17567A
Heparin sodium salt
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HY-116282M
Dextran sulfate, low sulfate (MW 40000)
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HY-15371
Forskolin
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HY-N0583
Hydrocortisone
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HY-112624K
Dextran T5 (MW 5,000)
Publications Citing Use of MedChemExpress (MCE) Dextran sulfate sodium salt (MW 5000)
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Biological Activity
Coagulation activity:
Dextran sulfate sodium salt (MW 5000) enhances C1 inhibitor's effect on FXIa, accelerates thrombin inhibition by Antithrombin and heparin cofactor II.
Dextran sulfate sodium salt (MW 5000) (0.01-1 mg/mL) inhibits macroscopic clotting, abrogates platelet consumption and completely blocks the generation of C3a, FXIa-Antithrombin and thrombin-antithrombin when human islets came in contact with ABO-compatible blood[1].
Antiviral activity:
Dextran sulfate sodium salt (MW 5000) (25 μg/mL; 24 h) completely protected MT-4 cells from HIV-1-induced cytopathogenicity[2].
Others:
Dextran sulfate sodium salt (MW 5000) can be labeled with 2-aminopyridine (yielding pyridylamino-DSS or PA-DSS) and be used to examine its metabolism in Caco-2 cells. PA-DSS (MW 5000) (3%; 24 h) rapidly inhibits the energy metabolism of Caco-2 cells[3].
Dextran sulfate sodium salt (MW 5000) (0-25 mg/mL, 6 h) protects human myoblasts from NK cell mediated killing[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9011-18-1
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Appearance Solid
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Molecular Weight 5000(Average)
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Color Off-white to light yellow
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Synonyms
DSS (MW 5000); DXS (MW 5000)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (5)
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Journal Impact Factor
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Most Recent
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Mol Cancer
Tumour-infiltrating microplastics disrupt the JAK-STAT-microbiota axis to promote immunotherapy resistance in colorectal cancer. [Abstract]2026 Feb 10;25(1):73. PMID: 41664174 -
Cancer Commun (Lond)
RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target. [Abstract]2025 Oct 16. PMID: 41103012 -
Int J Biol Macromol
Thermosensitive and mucoadhesive poloxamer 407/sodium alginate hydrogel loaded with spermidine for targeted autophagy activation and mucosal repair in ulcerative colitis. [Abstract]2026 Jan;335(Pt 1):149255. PMID: 41297803 -
Int Immunopharmacol
Human antigen R -mediated autophagy-related gene 3 methylation enhances autophagy-driven ferroptosis in Crohn's disease colitis. [Abstract]2025 May 8:154:114565. PMID: 40174340 -
Sci Total Environ
Water pollutant cadmium-induced intestinal inflammation in Eriocheir sinensis and potential therapeutic drugs. [Abstract]2024 Dec 10:955:177132. PMID: 39442721
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Johansson H, et al. Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant. 2006 Feb;6(2):305-12. [Content Brief]
[2]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6. [Content Brief]
[3]. Araki Y, et al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28(5):1597-605. [Content Brief]
[4]. Laumonier T,et al. Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Cell Transplant. 2013;22(7):1213-26. [Content Brief]
[5]. Banz Y, et al. Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model. J Vasc Surg. 2009 Jul;50(1):161-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dextran sulfate sodium salt (MW 5000) Related Classifications
HY-116282 Related Classifications
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