Dextran sulfate sodium salt (MW 450000-550000)
Based on 1 Customer Validation
Dextran sulfate sodium salt (DSS) (MW 450000-550000) is a polymer of dehydrated glucose with a molecular weight of approximately 450000-550000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 450000-550000) inhibits replication of HIV-1 and influenza A virus. Dextran sulfate sodium salt (MW 450000-550000) can be formulated as nanoparticles and shows antibacterial activity. Dextran sulfate sodium salt (MW 450000-550000) can be used for functional material preparation.
For research use only. We do not sell to patients.
- CAS No.: 9011-18-1
- Molecular Weight:450000-550000
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-116282C
Dextran sulfate sodium salt (MW 35000-45000)
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HY-116282
Dextran sulfate sodium salt (MW 5000)
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HY-116282B
Dextran sulfate sodium salt (MW 16000-24000)
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HY-W134327A
DEAE-dextran (MW 500000)
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HY-116282A
Dextran sulfate sodium salt (MW 4500-5500)
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HY-116282I
Dextran sulfate sodium salt (MW>500000)
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HY-116282M
Dextran sulfate, low sulfate (MW 40000)
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HY-W134327
DEAE-dextran (MW 40000)
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HY-112624P
Dextran T500 (MW 500,000)
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HY-112624
Dextran
Biological Activity
Antibacterial activity:
Dextran sulfate sodium (DSS) (MW 500000) nanoparticles can be formulated with gelation technique. The formulated DSS nanoparticles (MIC: 150-250 μg/mL) exhibits a spectrum of activity against Gram-positive and Gram-negative bacteria, such as E. coli, S. pyogenes, B. subtilis, K. pneumoniae, P. aeruginosa, S. aureus, and P. vulgaris[1].
Antiviral activity:
Dextran sulfate sodium (MW 500000) inhibits replication of HIV-1 in MT-4 cells (IC50: 10.9 μg/mL)[5].
Dextran sulfate sodium (MW 500000) (30 μg/mL) inhibits replication of HIV-1 in MT-4 cells[6].
Functional material preparation:
Dextran sulfate sodium (DSS) (MW 500000) can be incorporated into self-assembling PEI-DNA complexes (a non-viral gene delivery polymer) to reduce cytotoxicity[3].
Dextran sulfate sodium (DSS) (MW 500000) has haemocompatible property and interacts with blood components. DSS can covalent binds onto cellulose membrane for studying platelet adhesion ability of the modified membranes[4].
Others:
Dextran sulfate sodium (MW 450000-550000) (3% w/v) can be used for the isolation of neutrophils from human and rat blood[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9011-18-1
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Appearance Solid
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Molecular Weight 450000-550000
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Color White to off-white
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SMILES
[Dextran sulfate sodium salt (MW 450000-550000)]
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Synonyms
DSS (MW 450000-550000); DXS (MW 450000-550000)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Madkhali OA, et al. E. Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent. Sci Rep. 2021 May 10;11(1):9914. [Content Brief]
[2]. Aaltonen N, et al. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils. Biol Proced Online. 2020 Mar 15;22:6. [Content Brief]
[3]. Tiyaboonchai W, et al. Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles. Eur J Pharm Sci. 2003 Jul;19(4):191-202. [Content Brief]
[4]. Erdtmann M, et al. Photochemical immobilization of heparin, dermatan sulphate, dextran sulphate and endothelial cell surface heparan sulphate onto cellulose membranes for the preparation of athrombogenic and antithrombogenic polymers. Biomaterials. 1994 Oct;15(13):1043-8. [Content Brief]
[5]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6. [Content Brief]
[6]. Lüscher-Mattli M, et al. Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo. Antiviral Res. 1990 Jul;14(1):39-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dextran sulfate sodium salt (MW 450000-550000) Related Classifications
HY-116282D Related Classifications
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