Dextran sulfate sodium salt (MW 4500-5500)
Based on 1 Customer Validation
Dextran sulfate sodium salt (DSS) (MW 4500-5500) is a polymer of dehydrated glucose with a molecular weight of approximately 4500-5500. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 4500-5500) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 4500-5500) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (MW 4500-5500) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 4500-5500) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) inhibits instant blood-mediated inflammatory reaction (IBMIR).
For research use only. We do not sell to patients.
- CAS No.: 9011-18-1
- Molecular Weight:4500-5500
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-116282
Dextran sulfate sodium salt (MW 5000)
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HY-116282C
Dextran sulfate sodium salt (MW 35000-45000)
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HY-116282D
Dextran sulfate sodium salt (MW 450000-550000)
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HY-116282I
Dextran sulfate sodium salt (MW>500000)
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HY-116282M
Dextran sulfate, low sulfate (MW 40000)
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HY-116282B
Dextran sulfate sodium salt (MW 16000-24000)
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HY-116282H
Dextran sulfate sodium salt (MW 9000-20000)
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HY-116282J
Dextran sulfate, low sulfate (MW 5000)
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HY-116282P
Dextran sulfate, high sulfate (MW 5000)
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HY-116282W
Dextran sulfate sodium salt (MW 6500-10000)
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HY-125861
Methyl cellulose(Viscosity:100000mPa.s)
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HY-128868A
FITC-Dextran (MW 4000)
Biological Activity
Coagulation activity:
Dextran sulfate sodium salt (MW 5000) enhances C1 inhibitor's effect on FXIa, accelerates thrombin inhibition by Antithrombin and heparin cofactor II.
Dextran sulfate sodium salt (MW 5000) (0.01-1 mg/mL) inhibits macroscopic clotting, abrogates platelet consumption and completely blocks the generation of C3a, FXIa-Antithrombin and thrombin-antithrombin when human islets came in contact with ABO-compatible blood[1].
Antiviral activity:
Dextran sulfate sodium salt (MW 5000) (25 μg/mL; 24 h) completely protected MT-4 cells from HIV-1-induced cytopathogenicity[2].
Others:
Dextran sulfate sodium salt (MW 5000) can be labeled with 2-aminopyridine (yielding pyridylamino-DSS or PA-DSS) and be used to examine its metabolism in Caco-2 cells. PA-DSS (MW 5000) (3%; 24 h) rapidly inhibits the energy metabolism of Caco-2 cells[3].
Dextran sulfate sodium salt (MW 5000) (0-25 mg/mL, 6 h) protects human myoblasts from NK cell mediated killing[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9011-18-1
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Appearance Solid
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Molecular Weight 4500-5500
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Color White to off-white
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SMILES
[Dextran sulfate sodium salt (MW 4500-5500)]
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Synonyms
DSS (MW 4500-5500); DXS (MW 4500-5500)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (270 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Johansson H, et al. Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant. 2006 Feb;6(2):305-12. [Content Brief]
[2]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6. [Content Brief]
[3]. Araki Y, et al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28(5):1597-605. [Content Brief]
[4]. Laumonier T,et al. Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Cell Transplant. 2013;22(7):1213-26. [Content Brief]
[5]. Banz Y, et al. Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model. J Vasc Surg. 2009 Jul;50(1):161-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dextran sulfate sodium salt (MW 4500-5500) Related Classifications
HY-116282A Related Classifications
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