LAMP-2/CD107b
LAMP-2 (CD107b) is the second major lysosome-associated membrane glycoprotein and, like LAMP-1, carries bulky poly-lactosamine chains that shield the lysosomal membrane. A splice variant exposed at the cell surface serves as a receptor for chaperone-mediated autophagy, guiding cytosolic proteins bearing a KFERQ-like motif into lysosomes for degradation. Germline LAMP2 mutations cause Danon disease, an X-linked vacuolar cardiomyopathy with skeletal myopathy and variable intellectual disability. In immunology, CD107b marks degranulating cytotoxic lymphocytes together with CD107a and is enriched on macrophages, supporting its use as a histiocytic marker. LAMP-2 also contributes to phagosome-lysosome fusion and macrophage antimicrobial activity.
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LAMP-2/CD107b Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
