2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Activin/Inhibins

Activin/Inhibins

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The activins and inhibins are among the 33 members of the TGF-β family and were first described as regulators of follicle-stimulating hormone (FSH) secretion and erythropoiesis. The activins were originally recognized for their abilities to augment the gonadotropin-releasing hormone (GnRH)-mediated release of FSH, and were named “activins” because their effects were functionally opposite to those of inhibin in this context. Inhibins and activins share common β subunits, with inhibins occurring as αβ heterodimers, whereas activins are ββ homodimers. Because inhibins were discovered and isolated before activins, the β monomers are designated inhibins βA and βB, and the genes are Inhba and Inhbb, respectively[1].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70311
    Activin A Protein, Human/Mouse/Rat (HEK293)

    rHuActivin A; Inhibin beta A chain; INHBA; Activin A

    		Human HEK293
    Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin A Protein, Human/Mouse/Rat (HEK293) is produced in HEK293 cells, and consists of 117 amino acids (G310-S426).
  • HY-P700159AF
    Animal-Free Activin A Protein, Human/Mouse/Rat (His)

    Activin beta-A chain; EDF; Erythroid differentiation factor; Erythroid differentiation protein; Follicle stimulating hormone releasing protein; FRP; FSH releasing protein; INHBA; INHBA_HUMAN; Inhibin beta A chain; Inhibin beta A subunit; Inhibin, beta 1; Inhibin, beta A activin A, activin AB alpha polypeptide;

    		Human; Rat; Mouse E. coli
    The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. Animal-Free Activin A Protein, Human/Mouse/Rat (His) is the recombinant human, rat, mouse-derived animal-FreeActivin A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free Activin A Protein, Human/Mouse/Rat (His) is 116 a.a., with molecular weight of ~13.9 kDa.
  • HY-P75888
    INHBE Protein, Human (HEK293, Fc)

    Inhibin beta E chain; Activin beta-E chain; INHBE

    		Human HEK293
    The INHBE protein is an important molecular switch that coordinates the inhibin and activin systems to regulate pituitary follicle-stimulating hormone secretion. Its critical role extends to multiple physiological functions, including hormone secretion, cell development, insulin release, and bone growth. INHBE Protein, Human (HEK293, Fc) is the recombinant human-derived INHBE protein, expressed by HEK293 , with N-hFc labeled tag. The total length of INHBE Protein, Human (HEK293, Fc) is 114 a.a., with molecular weight of ~40.9 kDa.
  • HY-P73241
    Activin A Protein, Mouse (HEK 293, His)

    Activin beta-A chain; Activin A; Inhibin beta A chain; INHBA

    		Mouse HEK293
    Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin A Protein, Mouse (HEK293, His) is produced in HEK293 cellswith a C-Terminal His-tag. It  consists of 424 amino acids (M1-S424).
  • HY-P73242
    INHBB Protein, Human (HEK293, His)

    Activin beta-B chain; INHBB; Inhibin beta B chain

    		Human HEK293
    The INHBB protein complexly controls pituitary function, regulating follicle-stimulating hormone and activin. Its critical role extends to a variety of physiological processes, including hormone secretion, cell development, insulin release, and bone growth. INHBB Protein, Human (HEK293, His) is the recombinant human-derived INHBB protein, expressed by HEK293 , with C-10*His labeled tag. The total length of INHBB Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~17.52 & 40.53 & 53.75 kDa, respectively.
  • HY-P72295
    Inhibin alpha chain/INHA Protein, Bovine (His-SUMO)

    INHA; Inhibin alpha chain

    		Bovine E. coli
    Inhibin alpha chain/INHA protein plays a vital role in regulating pituitary function and contributes to the dual regulation of follicle-stimulating hormone secretion and activin. Inhibin alpha chain/INHA Protein, Bovine (His-SUMO) is the recombinant bovine-derived Inhibin alpha chain/INHA protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Inhibin alpha chain/INHA Protein, Bovine (His-SUMO) is 134 a.a., with molecular weight of ~33 kDa.
  • HY-P700013AF
    Animal-Free Activin B Protein, Human (His)

    Activin Beta B; INHBB; inhibin beta B chain

    		Human E. coli
    Activin B, a TGFβ superfamily cytokine, is a homodimer of activin βB subunits. Activin B binds to type II transmembrane serine-threonine kinase receptors (ACTRIIA or ACTRIIB) which, in turn, activate type I receptors (ACTRI) that phosphorylate and activate canonical SMAD signaling pathways. Animal-Free Activin B Protein, Human (His), a recombinant animal-free protein, is produced in E. coli with a C-Terminal His-tag. It consists of 115 amino acids (G293-407A).
  • HY-P70311G
    GMP Activin A Protein, Human/Mouse/Rat (HEK293)

    rHuActivin A; Inhibin beta A chain; INHBA; Activin A

    		Rat; Mouse; Human HEK293
    The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. GMP Activin A Protein, Human/Mouse/Rat (HEK293) is the recombinant rat, mouse, human-derived Activin A protein, expressed by HEK293 , with tag free. The total length of GMP Activin A Protein, Human/Mouse/Rat (HEK293) is 116 a.a., with molecular weight of 13-15 kDa.
  • HY-P70383
    Inhibin beta C chain/INHBC Protein, Human (HEK293, His)

    rHuInhibin beta C chain/INHBC, His; Inhibin Beta C Chain; Activin Beta-C Chain; INHBC

    		Human HEK293
    The inhibin beta C chain (INHBC) protein complexly regulates the inhibin and activin systems and balances follicle-stimulating hormone secretion. Its key roles span a variety of physiological processes, including hormone secretion, cell development, insulin release, and bone growth, depending on the specific subunit composition. Inhibin beta C chain/INHBC Protein, Human (HEK293, His) is the recombinant human-derived Inhibin beta C chain/INHBC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Inhibin beta C chain/INHBC Protein, Human (HEK293, His) is 334 a.a., with molecular weight of ~49.0 kDa.
  • HY-P73241A
    Activin A Protein, Mouse (HEK293, His)

    Activin beta-A chain; Activin A; Inhibin beta A chain; INHBA

    		Mouse HEK293
    Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin A Protein, Mouse (HEK293, His) is produced in HEK293 cellswith a C-Terminal His-tag. It  consists of 404 amino acids (S21-S424).
Cat. No. Product Name Effect Purity