2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Activin/Inhibins
  6. Activin B

Activin B

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Activin B, a TGFβ superfamily cytokine, is a homodimer of activin βB subunits. Activin B binds to type II transmembrane serine-threonine kinase receptors (ACTRIIA or ACTRIIB) which, in turn, activate type I receptors (ACTRI) that phosphorylate and activate canonical SMAD signaling pathways. Activins, members of the TGF-β superfamily, are first isolated from porcine ovarian follicular fluid and identified as activating factors for the release of follicle stimulating hormone. Activin B found in most tissues including placenta, reproductive organs, bone marrow, and brain. Activin B is a regulator of inflammation and immunity, and also involved in cancer or wound healing processes[1][2][3][4].
Activins exist different additional roles, including broad and complex effects on cell growth and differentiation, regulation of embryogenesis, development of the reproductive system, wound healing, stem cell differentiation and regulation of immune response. Activins exert their biological functions through the serine/threonine protein kinase (MAPKs) signaling pathways. Activin B might also signal through the type IC activin receptors (ACVR1C (ALK7)). The type I receptor initiates a signaling cascade by activating a phosphorylation cascade through SMAD2/3 that complexes with SMAD4 and translocates to the cell nucleus to modulate gene transcription[1][2][3].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73242
    INHBB Protein, Human (HEK293, His)

    Activin beta-B chain; INHBB; Inhibin beta B chain

    		Human HEK293
    The INHBB protein complexly controls pituitary function, regulating follicle-stimulating hormone and activin. Its critical role extends to a variety of physiological processes, including hormone secretion, cell development, insulin release, and bone growth. INHBB Protein, Human (HEK293, His) is the recombinant human-derived INHBB protein, expressed by HEK293 , with C-10*His labeled tag. The total length of INHBB Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~17.52 & 40.53 & 53.75 kDa, respectively.
  • HY-P700013AF
    Animal-Free Activin B Protein, Human (His)

    Activin Beta B; INHBB; inhibin beta B chain

    		Human E. coli
    Activin B, a TGFβ superfamily cytokine, is a homodimer of activin βB subunits. Activin B binds to type II transmembrane serine-threonine kinase receptors (ACTRIIA or ACTRIIB) which, in turn, activate type I receptors (ACTRI) that phosphorylate and activate canonical SMAD signaling pathways. Animal-Free Activin B Protein, Human (His), a recombinant animal-free protein, is produced in E. coli with a C-Terminal His-tag. It consists of 115 amino acids (G293-407A).
Cat. No. Product Name Effect Purity