Complement Factor H Related 1
Complement factor H-related protein 1 (CFHR1) is a plasma protein of five short consensus repeat domains encoded within the CFH gene cluster at chromosome 1q32. Although homologous to factor H, CFHR1 lacks strong complement-regulatory activity and instead binds C3b and C4b and associates with circulating C-reactive protein, likely fine-tuning complement activation at inflammatory sites and on microbial surfaces. Homozygous deletion of CFHR1 and CFHR3, common in many populations, protects against typical hemolytic uremic syndrome but predisposes to anti-factor H autoantibody-mediated disease. Recombinant CFHR1 is used in genotyping-correlated functional and autoimmunity studies.
-
Complement Factor H Related 1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
