CFHR1 Protein, Human (HEK293, His)

CFHR1, a key complement regulator, actively engages in the finely tuned complement system. Dimerized CFHR1 demonstrates avidity for tissue-bound complement fragments, challenging CFH. It also associates with lipoproteins, suggesting involvement in lipid metabolism. With a unique head-to-tail homodimeric structure, CFHR1 forms heterodimers with CFHR2 or CFHR5, showcasing its versatile role in complement-related processes. CFHR1 Protein, Human (HEK293, His) is the recombinant human-derived CFHR1 protein, expressed by HEK293 , with C-6*His labeled tag.

CFHR1 emerges as a pivotal figure in the intricate realm of complement regulation, showcasing its active involvement in this finely tuned system. In its dimerized forms, CFHR1 exhibits a remarkable avidity for tissue-bound complement fragments, effectively challenging the physiological complement inhibitor CFH. Beyond its regulatory prowess, CFHR1 displays an affinity for association with lipoproteins, hinting at a potential role in lipid metabolism. The unique structural arrangement of CFHR1 includes a head-to-tail homodimeric configuration, and it further forms heterodimers with CFHR2 or CFHR5, emphasizing its versatile engagement in the multifaceted orchestration of complement-related processes.

Immobilized Human CFHR1 at 1 μg/mL (100 μL/well) can bind Anti-CFHR1. The ED₅₀ for this effect is 183.9 ng/mL.

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  Immobilized Human CFHR1 at 1 μg/mL (100 μL/well) can bind Anti-CFHR1. The ED₅₀ for this effect is 183.9 ng/mL.

Human

HEK293

C-6*His

Q03591 (E19-R330)

3078  [NCBI]

Full Length of Mature Protein

EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR

38-50 kDa

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  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder

1.Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 8% trehalose, 4% mannitol, 50 mM NaCl, 0.05% Tween 80, pH 7.5.
2.Lyophilized from a 0.22 μm filtered solution of PBS, pH 8.0, 2 mM EDTA.
Please refer to the lot-specific COA for specific buffer information.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.