Copy Link Print Information

CFHR2 Protein, Human (HEK293, His)

Customer Review

Based on 1 Customer Validation

CFHR2, a key complement regulator, competently rivals CFH by avidly interacting with tissue-bound complement fragments. It also associates with lipoproteins, hinting at a role in lipid metabolism. With a distinctive head-to-tail homodimeric structure, CFHR2 forms heterodimers with CFHR1 or CFHR5, showcasing its versatile involvement in the regulatory dynamics of the complement system. CFHR2 Protein, Human (HEK293, His) is the recombinant human-derived CFHR2 protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • CFHR2 Protein, Human (HEK293, His) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Biological Activity

Description

CFHR2, a key complement regulator, competently rivals CFH by avidly interacting with tissue-bound complement fragments. It also associates with lipoproteins, hinting at a role in lipid metabolism. With a distinctive head-to-tail homodimeric structure, CFHR2 forms heterodimers with CFHR1 or CFHR5, showcasing its versatile involvement in the regulatory dynamics of the complement system. CFHR2 Protein, Human (HEK293, His) is the recombinant human-derived CFHR2 protein, expressed by HEK293 , with C-6*His labeled tag.

Background

CFHR2 takes center stage in the intricate landscape of complement regulation. Functioning as a crucial player, it engages in avid interactions with tissue-bound complement fragments, showcasing its ability to competently rival the physiological complement inhibitor CFH. Moreover, CFHR2 demonstrates a propensity to associate with lipoproteins, suggesting a potential involvement in lipid metabolism. Adding to its complexity, CFHR2 exhibits a distinctive head-to-tail homodimeric structure and forms heterodimers with CFHR1 or CFHR5, underscoring its versatile role in the regulatory ballet of the complement system.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-6*His
  • Accession

    P36980-1 (E19-K270)

  • Gene ID
    3080  [NCBI]
  • Molecular Construction
    • N-term
    • CFHR2 (E19-K270)
      Accession # P36980-1
    • 6*His
    • C-term
  • Protein Length

    Full Length of Isoform-1

  • Synonyms

    CFHR2; H Factor-Like Protein 2; Prev. CFHL2; DDESK59; Prev. HFL3; FHR-2; FHR2; Complement Factor H-Related 2; Complement Factor H-Related Protein 2; Factor H-Related Gene 2; H Factor (Complement)-Like 3; Complement Factor H Related 2; H Factor-Like 3

  • AA Sequence

    EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK

  • Predicted Molecular Mass

    29.8 kDa

  • Molecular Weight

    Approximately 31 kDa & 35 kDa, based on SDS-PAGE under reducing conditions.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 200 mM NaCl, 2 mM EDTA, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) Volume (to add to vial)
=
Mass (in vial) Mass (in vial)
÷
Desired Reconstitution Concentration Desired Reconstitution Concentration
Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

Concentration (start) Concentration (start)
×
Volume (start) Volume (start)
=
Concentration (final) Concentration (final)
×
Volume (final) Volume (final)
The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • CFHR2 Protein, Human (HEK293, His) Product Image
    1/16
  • CFHR2 Protein, Human (HEK293, His) Product Image