IL-17 Receptor

IL-17 receptor family is composed of five members from IL-17RA to IL-17RE. The subunit IL-17RA is ubiquitous and is a common co-receptor subunit for other members of the IL-17 family. IL-17RA pairs with IL-17RC to bind either IL-17A or IL-17F as covalent homodimers, but also IL-17A/IL-17F as heterodimers. However, the association of IL-17RA with other members of the IL-17 receptor family shifts the affinity toward other members of the IL-17 family[1].