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  6. IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi)

IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi)

Cat. No.: HY-P78147
Handling Instructions

IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F. IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi), a Biotinylated  IL-17RA protein, is produced in  HEK293 cells with a C-Terminal Fc-tag and a C-Terminal Avi-tag. It consists of 288 amino acids (L33-W320).

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Description

IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F[1][2]. IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi), a Biotinylated  IL-17RA protein, is produced in  HEK293 cells with a C-Terminal Fc-tag and a C-Terminal Avi-tag. It consists of 288 amino acids (L33-W320).

Background

Interleukin-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that binds interleukin 17. IL-17RA is a proinflammatory cytokine secreted by activated T-lymphocytes. IL-17 receptor family is composed of five members from IL-17RA to IL-17RE. The subunit IL-17RA is ubiquitous and is a common co-receptor subunit for other members of the IL-17 family. The IL-17RA gene is mapped to human chromosome 22q11.1 and is expressed ubiquitously and exhibits a broad tissue distribution[1][2].
The amino acid sequence of human IL17RA protein has low homology between mouse and rat IL-17A protein.
IL-17A, the prototypic T helper 17 (Th17) cytokine, is important in host defense at mucosal surfaces, but also functions as an important inflammatory mediator involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). IL-17RA pairs with IL-17RC to bind either IL-17A or IL-17F as covalent homodimers, but also IL-17A/IL-17F as heterodimers. IL-17RA offers protection against pathogenic infection as it plays an important role in host defence mechanism. IL-17A activates downstream cellular signaling through IL-17 receptor (IL-17R) complex comprised of the IL-17A receptor (IL-17RA) and IL-17C receptor (IL-17RC) subunits with higher affinity to IL-17RA. The IL-17A/IL-17RA axis has been implicated in the pathogenesis of several acute and chronic airway and lung diseases. However, the association of IL-17RA with other members of the IL-17 receptor family shifts the affinity toward other members of the IL-17 family. Indeed, combination of IL-17RA with IL-17RB binds IL-17E as covalent homodimers. Besides, IL-17RA can also associate with IL-17RE to bind IL-17C as homodimers. However, the involvement of IL-17RA is not compulsory, as IL-17RB forms homodimers to target IL-17B as covalent homodimers[1][2][3].
IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RA involved in antimicrobial host defense and maintenance of tissue integrity. It has been demonstrated in infectious models in which neutrophils are crucial for host defense, that IL-17RA deficiency results in reduced chemokine levels and reduced neutrophil numbers, and increased susceptibility to infection. In addition, IL-17RA is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5). IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis[1][2][3][4].

In Vitro

IL-17RA Protein, Human (1 μg/mL; 72 hours) preincubated with IL-2 plus IL-25 for 3 min before addition to the PBMC cultures, the result shows IL-17RA does not inhibit IL-5 production in response to stimulation by IL-25 plus IL-2[5].

Species

Human

Source

HEK293

Tag

C-Avi;C-hFc

Accession

Q96F46 (L33-W320)

Gene ID
Synonyms
CD217; CDw217; IL-17RA; IL17R; CANDF5; IL-7R; IL-7R-alpha; ILRA
Molecular Weight

78-100 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
References
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi)
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