IL17RA - interleukin 17 receptor A Gene

Also Known as CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23765

About IL17RA

Cytogenetic location: 22q11.1 Genomic coordinates (GRCh38): 22:17,085,000-17,115,693 (from NCBI)

This gene has 8 transcripts (splice variants), 241 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues.

Summary

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other Cytokine Receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

IL17RA Products (2)

mRNA	Protein	Name
NM_001289905.2	NP_001276834.1	interleukin-17 receptor A isoform 2 precursor
NM_014339.7	NP_055154.3	interleukin-17 receptor A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-17 receptor activity	IDA IDA: Inferred from direct assay	27184415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21993848	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fibroblast activation	IDA IDA: Inferred from direct assay	21145111	GOA
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	33723527	GOA
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21350122	GOA
involved in interleukin-17A-mediated signaling pathway	IDA IDA: Inferred from direct assay	9367539	GOA
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	21350122	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	33723527	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	33723527	GOA
involved in positive regulation of interleukin-23 production	IDA IDA: Inferred from direct assay	21145111	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21350122	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	33723527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17RA Protein Structure

SEFIR

0
200
400
600
800
866 a.a.

Protein Preferred Names	Protein Names
interleukin-17 receptor A	IL-17 receptor A

IL17RA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	IL17RA	Q96F46	ns8_sars2	SARS-CoV-2	P0DTC8	Pull Down	33060197
Intra	IL17RA	Q96F46	IL17RE	Homo sapiens	Q8NFR9	Anti Tag CoIP	21993848

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL17RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70892	IL-17RA Protein, Human (HEK293, His)	Q96F46-1 (L33-W320)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71963	IL-17RA Protein, Human (HEK293, hFc)	Q96F46-1 (L33-W320)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78147	IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q96F46-1 (L33-W320)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78161	IL-17RA Protein, Human (Biotinylated, HEK293, His-Avi)	Q96F46-1 (L33-W320)	≥ 95%, as determined by Bis-Tris PAGE.

IL17RA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81634	IL-17RA Antibody (YA1379)	FC, ELISA	Human
HY-P82900	IL-17RA Antibody (YA2645)	WB, IP	Human

Related Diseases

Diseases	Alias
Immunodeficiency 51	IMD51 Candf5 Candidiasis, Familial, 5 Candidiasis, Familial, 5, Formerly Candf5, Formerly Familial Candidiasis 5 Candidiasis Familial 5 Autosomal Recessive Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive Chronic Mucocutaneous Candidiasis 5
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Psoriasis
Folliculitis
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Colitis
Cutaneous Candidiasis	Candidiasis, Cutaneous
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Fungal Infectious Disease	Mycoses Mycosis
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Autoimmune Disease Of Skin And Connective Tissue
Vulvovaginal Candidiasis	Candidiasis Of Vulva And Vagina Candidiasis, Vulvovaginal Candidal Vulvovaginitis Candidal: Cervix Monilial Vulvovaginitis Candidiasis Vulvovaginal
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Ankylosing Spondylitis 1	Ankylosing Spondylitis, Susceptibility To, 1
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Meningovascular Neurosyphilis
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9924	Ixekizumab	Inhibitor	99.00%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991266	SM-17	Inhibitor	96.98%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18197	Il17ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178714	JNJ627	Inhibitor	/	Unkown
HY-RS06702	IL17RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174632	Human IL17RA mRNA		/	Unkown
HY-RS24671	Il17ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL17RA	VGNC	VGNC:67763
Canis familiaris	IL17RA	VGNC	VGNC:41946
Macaca mulatta	IL17RA	VGNC	VGNC:73712
Mus musculus	IL17RA	MGD	MGI:107399
Rattus norvegicus	IL17RA	RGD	RGD:1306559
Bos taurus	IL17RA	VGNC	VGNC:30122
Others	IL17RA	NCBI