IL-17A antagonist 1
Based on 3 publication(s) in Google Scholar
IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 2205034-18-8
- Formula: C33H41FN6O4
- Molecular Weight:604.71
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) IL-17A antagonist 1
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Biological Activity
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IL-17A 1.14 nM (IC50) |
IL-17A 0.66 μM (Kd) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Keratinocyte | IC50 |
>10 μM
Compound: Fig 1, Cpd 3
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Inhibition of IL-8 production in human keratinocytes
Inhibition of IL-8 production in human keratinocytes
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[PMID: 34100601] |
IL-17A antagonist 1 (compound 1) specifically binds to recombinant human IL-17A dimer with a Kd of 0.660 μM, and does not bind to IL-17F or IL-17RA at concentrations up to 40 μM[1].
IL-17A antagonist 1 (1 h pre-incubation, 3 h post IL-17RA addition) inhibits the interaction between IL-17A and IL-17RA in a cell-free FRET assay with an IC50 of 1.14 μM[1].
IL-17A antagonist 1 (up to 10 μM; 48 h) does not inhibit IL-17A + TNF−α-stimulated IL-8 production in primary human keratinocytes at concentrations up to 10 μM[1].
IL-17A antagonist 1 binds to a central pocket at the IL-17A dimer interface, inducing a large conformational rearrangement of IL-17A that reduces dimer stability and disrupts IL-17A/IL-17RA interaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2205034-18-8
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Appearance Solid
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Molecular Weight 604.71
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Formula C33H41FN6O4
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Color White to off-white
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SMILES
O=C(N(C)C)CC1(CC(NCCC2=CC=C(NC([C@H](CC3=CC=CC=C3F)NC(C4=CC=NN4C)=O)=O)C=C2)=O)CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Redox Biol
Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation. [Abstract]2023 Dec:68:102970. PMID: 38035662 -
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Funct Integr Genomics
Unraveling the role of IL-17 signaling pathway in breast cancer-related depression: insights from in vivo/in vitro models and transcriptomic analysis. [Abstract]2026 Jan 29;26(1):33. PMID: 41606389
Solvent & Solubility
DMSO : 41.67 mg/mL (68.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6537 mL | 8.2684 mL | 16.5369 mL | 41.3421 mL |
| 5 mM | 0.3307 mL | 1.6537 mL | 3.3074 mL | 8.2684 mL | |
| 10 mM | 0.1654 mL | 0.8268 mL | 1.6537 mL | 4.1342 mL | |
| 15 mM | 0.1102 mL | 0.5512 mL | 1.1025 mL | 2.7561 mL | |
| 20 mM | 0.0827 mL | 0.4134 mL | 0.8268 mL | 2.0671 mL | |
| 25 mM | 0.0661 mL | 0.3307 mL | 0.6615 mL | 1.6537 mL | |
| 30 mM | 0.0551 mL | 0.2756 mL | 0.5512 mL | 1.3781 mL | |
| 40 mM | 0.0413 mL | 0.2067 mL | 0.4134 mL | 1.0336 mL | |
| 50 mM | 0.0331 mL | 0.1654 mL | 0.3307 mL | 0.8268 mL | |
| 60 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6890 mL |
IL-17A antagonist 1 Related Classifications
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