2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-17
  6. IL-17A

IL-17A

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Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+ T cells[1]. In addition to Th17 cells, IL-17A is also produced by a wide variety of immune cells, including CD8+ T cells, γδT cells, natural killer T (NKT) cells, monocytes, and neutrophils[2][3]. IL-17A plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses[1][2]. IL-17A induces the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13)[2]. IL-17A is detrimental in viral infection through promoting neutrophilic inflammation[1]. IL-17A is a homodimeric cytokine and shares similar biological activities with IL-17F. IL-17A binds to IL-17RA with high affinity, and IL-17RA is required for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells that are deficient in IL-17RA. IL-17A has been implicated in a variety of autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis[4]. IL-17A also plays a pathogenic role in cancer. In tumorigenesis, IL-17A recruits myeloid derived suppressor cells (MDSCs) to dampen anti-tumor immunity. IL-17A also enhances tumor growth in vivo through the induction of IL-6[1]. Murine IL-17A is a 21 kDa glycoprotein with 147 amino acids and 63% amino acid homology with human IL-17A (155 amino acids)[2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7036
    IL-17A Protein, Human

    rHuIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

    		Human E. coli
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human is a recombinant human IL-17A protein and is expressed in E. coli. It consists of 137 amino acids (I19-A155).
  • HY-P70753
    IL-17A Protein, Mouse (HEK293, His)

    Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17

    		Mouse HEK293
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (HEK293, His) is a recombinant mouse IL-17A protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 137 amino acids (T22-A158).
  • HY-P70527
    IL-17A Protein, Human (HEK293, His)

    Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17

    		Human HEK293
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (HEK293, His) is a recombinant human IL-17A protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 132 amino acids (G24-A155).
  • HY-P7373
    IL-17A Protein, Human (CHO, His)

    rHuIL-17A, His; CTLA-8; IL-17A

    		Human CHO
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (CHO, His) is a recombinant human IL-17A protein with His tag at the C-terminus and is expressed in CHO cells. It consists of 132 amino acids (G24-A155).
  • HY-P73174
    IL-17A Protein, Mouse

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Mouse E. coli
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse is a recombinant mouse IL-17A protein and is expressed in E. coli. It consists of 137 amino acids (T22-A158).
  • HY-P73171
    IL-17A Protein, Human (CHO)

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Human CHO
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (CHO) is a recombinant human IL-17A protein and is expressed in CHO cells. It consists of 155 amino acids (M1-A155).
  • HY-P78157
    IL-17A Protein, Human (Biotinylated, 132a.a, HEK293, His-Avi)

    CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A

    		Human HEK293
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (Biotinylated, 132a.a, HEK293, His-Avi) is a biotinylated recombinant human IL-17A protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 132 amino acids (G24-A155).
  • HY-P78158
    IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi)

    CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A

    		Mouse HEK293
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant mouse IL-17A protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (A26-A158).
  • HY-P700104AF
    Animal-Free IL-17A Protein, Human (His)

    Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

    		Human E. coli
    The IL-17A protein is an important effector cytokine that is critical in both innate and adaptive immunity to defend against microorganisms and maintain tissue integrity. It acts through the IL17RA-IL17RC heterodimeric receptor complex, triggering signaling pathways, activating immune-related gene transcription and promoting strong immune inflammation. Animal-Free IL-17A Protein, Human (His) is the recombinant human-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17A Protein, Human (His) is 136 a.a., with molecular weight of ~16.47 kDa.
  • HY-P700194AF
    Animal-Free IL-17A Protein, Mouse (His)

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Mouse E. coli
    IL-17A protein is an important effector cytokine that activates the NF-kappa-B and MAPkinase pathways through the IL17RA-IL17RC receptor complex to protect host tissues from microbial threats. As a key Th17 cytokine, IL-17A mediates neutrophil activation, chemotaxis, and contributes to germinal center formation. Animal-Free IL-17A Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17A Protein, Mouse (His) is 133 a.a., with molecular weight of ~15.92 kDa.
  • HY-P7372
    IL-17A Protein, Mouse (CHO)

    rMuIL-17A; CTLA-8; IL-17A

    		Mouse CHO
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (CHO) is a recombinant mouse IL-17A protein and is expressed in CHO cells. It consists of 133 amino acids (A26-A158).
  • HY-P72589
    IL-17A (136a.a)-17F Heterodimer Protein, Human (HEK293, His)

    IL-17A/F Heterodimer; IL-17A&IL-17F Heterodimer

    		Human HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A (136a.a)-17F Heterodimer Protein, Human (HEK293, His) is a recombinant human IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 269 amino acids (IL-17A (I20-A155) & IL-17F (R31-Q163)).
  • HY-P73175
    IL-17A Protein, Rabbit

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Rabbit E. coli
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rabbit is a recombinant rabbit IL-17A protein and is expressed in E. coli. It consists of 130 amino acids (G24-A153).
  • HY-P73176
    IL-17A Protein, Rabbit (sf9, His)

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Rabbit Sf9 insect cells
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rabbit (sf9, His) is a recombinant rabbit IL-17A protein with His tag at the N-terminus and is expressed in sf9 insect cells. It consists of 130 amino acids (G24-A153).
  • HY-P77708
    IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi)

    IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F

    		Mouse HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant mouse IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 266 amino acids (IL-17A (A26-A158) & IL-17F (R29-A161)).
  • HY-P700246AF
    Animal-Free IL-17A Protein, Pig (His)

    Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17

    		Pig E. coli
    IL-17A Protein, part of the IL-17 family, is highlighted. Animal-Free IL-17A Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-17A protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-17A Protein, Pig (His) is 130 a.a., with molecular weight of ~15.81 kDa.
  • HY-P73174A
    IL-17A Protein, Mouse (E. coli)

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Mouse E. coli
    IL-17A protein is an important effector cytokine that activates the NF-kappa-B and MAPkinase pathways through the IL17RA-IL17RC receptor complex to protect host tissues from microbial threats. As a key Th17 cytokine, IL-17A mediates neutrophil activation, chemotaxis, and contributes to germinal center formation. IL-17A Protein, Mouse (E. coli) is the recombinant mouse-derived IL-17A protein, expressed by E. coli , with tag free. The total length of IL-17A Protein, Mouse (E. coli) is 137 a.a., with molecular weight of ~11-15 kDa.
  • HY-P73172
    IL-17A Protein, Human (T26A, sf9, His)

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Human Sf9 insect cells
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (sf9, His) is a recombinant human IL-17A protein with His tag at the N-terminus and is expressed in sf9 insect cells. It consists of 132 amino acids (G24-A155).
  • HY-P78320
    IL-17A Protein, Mouse (HEK293, His-Avi)

    CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A

    		Mouse HEK293
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (HEK293, His-Avi) is a recombinant mouse IL-17A protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (A26-A158).
  • HY-P73177
    IL-17A Protein, Rhesus macaque (sf9)

    CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

    		Rhesus Macaque Sf9 insect cells
    IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rhesus macaque (sf9) is a recombinant rhesus macaque IL-17A protein and is expressed in sf9 insect cells. It consists of 155 amino acids (M1-A155).
Cat. No. Product Name Effect Purity