1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-17
  5. IL-17A
  6. IL-17A Protein, Human

IL-17A Protein, Human

Cat. No.: HY-P7036
Handling Instructions

IL-17A Protein, Human is a proinflammatory cytokine.

For research use only. We do not sell to patients.

Protein Expression Service

Size Price Stock Quantity
10 μg $140 In-stock
Estimated Time of Arrival: December 31
50 μg $300 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

  • References

Description

IL-17A Protein, Human is a proinflammatory cytokine.

Background

The interleukin-17 (IL-17) cytokines, IL-17A to IL-17F, are emerging as critical players in host defence responses and inflammatory diseases. The interleukin-17 (IL-17) cytokines are emerging as key players in immune responses. The first member to be identified, IL-17A, is originally cloned as cytotoxic T-lymphocyte antigen-8, a gene sharing homology with the HSV13 gene from herpesvirus Saimiri. The other members, IL-17B to IL-17F are subsequently identified based on their homology to IL-17A. These proteins are highly conserved at the C terminus, and contain five spatially conserved cysteine residues that mediate dimerization. Members of the IL-17 receptor family, IL-17RA to IL-17RE, mediate the biological functions of these cytokines. Accumulating evidence indicates that these interactions induce pro-inflammatory programmes[1].

Biological Activity
Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells and the ED50 is <10 ng/mL.
Species

Human

Source

E. coli

Accession

Q16552 (I19-A155)

Gene ID
Synonyms
rHuIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
AA Sequence

IVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

Molecular Weight

Approximately 17.0 kD

Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against 20 mM PB, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
References

IL-17A Protein, Human Related Classifications

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Active Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-17A Protein, Human
Cat. No.:
HY-P7036
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