BAY 11-7082

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 Jul 10;41(7):1294-1308.e8. [Abstract]

(left) WT, Adrb2, Metrnl and Smpdl3b knockdown MDSCs were co-cultured with LPS for 5 min. Immunoblot analysis of signaling associated proteins (as indicated) and phosphorylated (p-) proteins in these three type cells. (right) WT, 3xKD BM-MDSCs and BAY 11-7082 treated 3xKD BM-MDSCs (for 24hr) were co-cultured with LPS for 5 min. Immunoblot analysis of nuclear RELA.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2023 Jul;26(7):1170-1184. [Abstract]

Bay 11-7082 (10 µM; 1 h). LPS ( 50 ng/μL; 3 h) Relative B2m mRNA expression levels in primary microglia under differing treatment conditions are shown in (h) (Control and oAβ, n = 3 biologically independent samples; LPS, n = 4 biologically independent samples; two-sided one-way ANOVA followed by Tukey’s multiple comparisons test).

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2018 Oct 19;15(1):291. [Abstract]

Real-time PCR analysis shows that meningitic E. coli strains PCN033- and RS218-induced proinflammatory cytokines production is significantly decreased via NF-κB signaling inhibition with 10 μM of BAY11-7082.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2018 Aug 1:428:77-89. [Abstract]

Western blots show that the NF-κB inhibitors BAY11-7082, Parthenolide, and JSH-23 cause dramatic time- and dose-dependent reductions in MGMT protein expression in LN18 and T98G glioma cells.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2023 Jul;12(19):e2203051. [Abstract]

Western blot images of p-p65, p65, IκBα, and MAP2 in NSCs co-cultured with 0 µg mL−1 Laponite nanoplatelets (Ctrl), 10 µg mL−1 Laponite nanoplatelets (LAP), 10 ng mL−1 TNF-α (TNF-α) (2 h), 10 µg mL−1 Laponite nanoplatelets, or 10 µm BAY11-7082 (2 h) (LAP+BAY) on day 5.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 29;9(9):880. [Abstract]

NF-κB inhibitor Bay 11-7082 treatment inhibits the activation of SOX4 and EMT process induced by CXCL1.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2017 Oct:229:964-975. [Abstract]

NF-κB-dependent immune responses in testicular cells. Sertoli cells (SC), Leydig cells (LC), and germ cells (GC) are pretreated with BAY11-7082 (BAY) at 2 μM for 1 h, followed by the addition of MC-LR into the culture medium to a final concentration of 1 μM and incubation for 6 h. Expression of phosphorylated NF-κB p65 (p-p65) and total p65 is measured by western blotting. The ratio of p-65/p65 is determined by densitometry and is expressed as means±SEM (n=5).

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Jul;75(14):2627-2641. [Abstract]

RAW264.7 macrophages are pre-treated with the inhibitor of ERK, JNK, P38, P65, and AKT signal pathway.Western blot analyzes the non- and phosphorylation of ERK, JNK, P38, P65, and AKT.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Mar;75(6):1117-1132. [Abstract]

Sertoli cells (SC) are pretreated with BAY11-7082 at 2 μM for 1 h, followed by the addition of MC-LR into the culture medium. Expression of p-p65 and MMP-8 is measured by western blotting.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Front Immunol. 2018 Sep 19:9:2121. [Abstract]

RPMI 2650 cells is incubated with or without IL-17A (100 ng/mL)+BAY 11-7082 (5 μM) for 24 h. WB is performed to measure the expression of MMP-9 protein levels.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Eur J Med Chem. 2017 Oct 20:139:337-348. [Abstract]

The cells are treated with different concentrations of compound 6k, and then in the presence or absence of LPS (1 μg/mL) for 24 h. Bay 11-7082 is the NF-κB inhibitors (20 μM). The results are showed as means±SD (n=3) of at least three independent experiments.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2017 Sep:50:30-37. [Abstract]

BV-2 cells are pretreated with or without Bay11-7082 (10 μM) for 30 min, and then incubated with 20 μM Aβ_1–42 for 24 h. The protein expression of TNF-α, IL-1β, and IL-6 are detected by western blot.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2016 Oct:39:149-157. [Abstract]

AOPPs-induced increase in catabolic factors is regulated by NF-κB activation. Chondrocytes are pretreated with or without NF-κB specific inhibitor Bay11-7082 (0.5 μM), followed by AOPPs treatment. NF-κ B p65 phosphorylation, IκB-α degradation and catabolic factors are detected by Western blot analysis. GAG production is determined by DMB method. Addition of Bay11-7082 blocks AOPPs-induced phosphorylation of NF-κB p65 and prevents degradation of IκB-α.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Cancer Biol Ther. 2018 Mar 4;19(3):222-229. [Abstract]

Western blot analysis of PIK3R3, TP, p-P65, P65 expression after transfected with PIK3R3 at the presence of BAY11-7082.

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Lab Invest. 2018 Apr;98(4):462-476. [Abstract]

Caco-2BBe cells are pretreated with BAY-11-7082 for 30 min and then treated with TNF-α (100 ng/mL) for 6 h. BAY-11-7082 treatment prevented the TNF-α-induced decrease in downregulated in adenoma (DRA).

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: BMC Cancer. 2019 Jan 8;19(1):30. [Abstract]

The representative images and analysis of western blot for IκBα、p-IκBα and nuclear p65 in CRC cells and expression levels of E-cadherin, N-cadherin and fibronectin in SW620 and HCT116 cells are measured by western blot treated with BAY 11-7082 (inhibitor of NF-κB pathway).

BAY 11-7082 purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2017 May 15:323:44-52. [Abstract]

The HUVECs are subjected to NF-κB inhibitor BAY 11-7082 (10 μM) for 1 h prior to MGO (1.0 mM) treatment for 24 h, then Bcl-2/ Bax ratio are determined by western blot.