USP28

Ubiquitin-specific protease 28

USP28 is a crucial deubiquitinase (DUB) in the ubiquitin-proteasome system and is highly expressed in many types of human cancer. USP28 is the third DUB, only after OTUB1 and USP7, which has been successfully hijacked to generate effective DUBTACs. Moreover, USP28 has been shown to regulate the stability of several critical proteins involved in the DNA damage response, such as 53BP1 and Claspin, thereby influencing the ability of the cell to repair DNA damage and maintain genomic integrity. The aberrant high expression or activity of USP28 is linked to various types of cancer, including breast, colorectal, and lung cancers, making USP28 a potential cancer drug target.

References:

[1]. Serra RW, et al. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12;3:e02313. [Content Brief]

[2]. Wang Z, et al. USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment. J Am Chem Soc. 2025 Apr 23;147(16):13754-13763.

USP28 Inhibitor (1)

USP28 Related Products (1):

By Type:	Selective (1)

Cat. No.	Product Name	Effect	Purity

HY-184244

CAS-010	Inhibitor

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