USP28
USP28 is a crucial deubiquitinase (DUB) in the ubiquitin-proteasome system and is highly expressed in many types of human cancer. USP28 is the third DUB, only after OTUB1 and USP7, which has been successfully hijacked to generate effective DUBTACs. Moreover, USP28 has been shown to regulate the stability of several critical proteins involved in the DNA damage response, such as 53BP1 and Claspin, thereby influencing the ability of the cell to repair DNA damage and maintain genomic integrity. The aberrant high expression or activity of USP28 is linked to various types of cancer, including breast, colorectal, and lung cancers, making USP28 a potential cancer drug target.
References:
- [1]. Serra RW, et al. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12;3:e02313. [Content Brief]
- [2]. Wang Z, et al. USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment. J Am Chem Soc. 2025 Apr 23;147(16):13754-13763. [Content Brief]
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USP28 Related Products (1)
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CAS-010
0 ImagesCat. No.: HY-184244CAS No.: 3094094-17-1Synonyms: CAS-13312-010CAS-010 (CAS-13312-010) is a potent and selective USP28 inhibitor with an IC50 of 2.2 nM against full-length USP28. CAS-010 acts as a ubiquitin-competitive inhibitor and shows higher selectivity over USP25 (IC50 = 51 nM) and other USP family members, disrupting the 53BP1-USP28 interaction and suppressing p53-dependent transcription of CDKN1A (p21), MDM2, and BAX. CAS-010 can be used for studying USP28-mediated DNA damage response and p53 signaling in cancer-related research.
