3094094-17-1
Chemical Structure
CAS-010
Synonym(s): CAS-13312-010
- CAS No.: 3094094-17-1
- Formula:C26H32N4OS
- Molecular Weight:448.62
InChIKey: RRZHXBAYYCRAGF-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)C2=C(N=C(CCC)C=C2)S1)NCCC3=CC=C(C4CC5NC(C4)CC5)C=C3
Biological Activity: CAS-010 (CAS-13312-010) is a potent and selective USP28 inhibitor with an IC50 of 2.2 nM against full-length USP28. CAS-010 acts as a ubiquitin-competitive inhibitor and shows higher selectivity over USP25 (IC50 = 51 nM) and other USP family members, disrupting the 53BP1-USP28 interaction and suppressing p53-dependent transcription of CDKN1A (p21), MDM2, and BAX. CAS-010 can be used for studying USP28-mediated DNA damage response and p53 signaling in cancer-related research[1].
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CAS-010 | CAS-010 (CAS-13312-010) is a potent and selective USP28 inhibitor with an IC50 of 2.2 nM against full-length USP28. CAS-010 acts as a ubiquitin-competitive inhibitor and shows higher selectivity over USP25 (IC50 = 51 nM) and other USP family members, disrupting the 53BP1-USP28 interaction and suppressing p53-dependent transcription of CDKN1A (p21), MDM2, and BAX. CAS-010 can be used for studying USP28-mediated DNA damage response and p53 signaling in cancer-related research. | |||||||||||||||||||||
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Keywords
