2. Signaling Pathways
  3. GPCR/G Protein
  4. GPR65

GPR65

G Protein-Coupled Receptor 65

GPR65 is a cell-surface receptor and belongs to the family of proton-activated G-protein-coupled receptors (GPCRs). As a pH sensor, GPR65 is expressed in metabolically important organs such as the liver and in immune cells. Tissue injury and inflammation are usually accompanied by local acidification and changes in pH values, which can be sensed by various activated GPCRs, including GPR65. GPR65 is involved in the regulation of immune responses, affecting the proliferation, differentiation of immune cells, and the secretion of cytokines. GPR65 plays a role in inflammatory responses and the maintenance of immune homeostasis. GPR65 also contributes to maintaining the integrity of the mucosal membrane and the balance of the gut microbiota. GPR65 is closely related to the development of various diseases such as hepatic fibrosis, inflammatory diseases, tumors, and neurological diseases, and is a potential therapeutic target[1].

GPR65 Related Products (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149164
    BTB09089
    		Agonist 99.39%
    BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages.
    BTB09089
  • HY-162734
    BRD5075
    		Activator 98.08%
    BRD5075 is a selective GPR65 activator. BRD5075 enhances GPR65 activity under acidic conditions, promotes Gαs-dependent signaling pathways, including cAMP production and G protein recruitment. BRD5075 regulates the cytokine and chemokine expression network in dendritic cells, and inhibits the expression of pro-inflammatory cytokines and chemokines in a GPR65-dependent manner. BRD5075 is applicable to research related to inflammatory bowel disease.
    BRD5075
  • HY-W193844
    MLS001006105
    		Agonist
    MLS001006105 (ZINC13684400) is a GPR65 allosteric agonist. MLS001006105 displays GPR65 allosteric agonist activity at pH 8.40 but not at lower pH.
    MLS001006105
  • HY-162735
    BRD5080
    		Activator 99.44%
    BRD5080 is a potent GPR65 positive allosteric modulator. BRD5080 induces GPR65-dependent cAMP production. BRD5080 exhibits a robust induction of cAMP activity and recruits G protein for the WT and variant hGPR65 as well as for the mouse ortholog. BRD5080 has the potential for autoimmune and inflammatory diseases research.
    BRD5080