2. Signaling Pathways
  3. GPCR/G Protein
  4. GPR65
  5. GPR65 Activator

GPR65 Activator

GPR65 Activators (2):

Cat. No. Product Name Effect Purity
  • HY-162734
    BRD5075
    		Activator 98.08%
    BRD5075 is a selective GPR65 activator. BRD5075 enhances GPR65 activity under acidic conditions, promotes Gαs-dependent signaling pathways, including cAMP production and G protein recruitment. BRD5075 regulates the cytokine and chemokine expression network in dendritic cells, and inhibits the expression of pro-inflammatory cytokines and chemokines in a GPR65-dependent manner. BRD5075 is applicable to research related to inflammatory bowel disease.
  • HY-162735
    BRD5080
    		Activator 99.44%
    BRD5080 is a potent GPR65 positive allosteric modulator. BRD5080 induces GPR65-dependent cAMP production. BRD5080 exhibits a robust induction of cAMP activity and recruits G protein for the WT and variant hGPR65 as well as for the mouse ortholog. BRD5080 has the potential for autoimmune and inflammatory diseases research.