1. GPCR/G Protein
  2. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Related Products (149):

Cat. No. Product Name Effect Purity
  • HY-13715B
    Norepinephrine bitartrate monohydrate Agonist 99.75%
    Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
  • HY-B0468
    Isoprenaline hydrochloride Agonist 99.97%
    Isoprenaline Hydrochloride is a non-selective beta-adrenergic agonist and structurally similar to adrenaline.
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride Agonist 99.40%
    (R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist Target: α1- Adrenergic Receptor Phenylephrine (PE), an alpha-adrenergic agonist and promoter of hypertrophic growth in the ventricular myocyte, to activate the three best-characterized mitogen-activated protein kinase (MAPK) subfamilies, namely p38-MAPKs, SAPKs/JNKs (i.
  • HY-13951
    ICI 118,551 hydrochloride Antagonist 99.00%
    ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
  • HY-B0573
    Propranolol hydrochloride Antagonist 99.57%
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM.
  • HY-17380
    (S)-Timolol Maleate Antagonist 98.89%
    (S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).
  • HY-12980
    Batefenterol Agonist 98.30%
    Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
  • HY-14301
    Olodaterol Agonist 98.37%
    Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.
  • HY-17453
    Salmeterol xinafoate Agonist
    Salmeterol xinafoate is a long-acting beta-2 adrenergic receptor (β2AR) agonist, with Ki of 1.5 nM for WT β2AR, and used for asthma treatment.
  • HY-B0447B
    L-Epinephrine Agonist 99.87%
    L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.
  • HY-B0162A
    Ivabradine hydrochloride Inhibitor 98.39%
    Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent.
  • HY-B0409A
    Clonidine hydrochloride Agonist 99.95%
    Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
  • HY-N0127
    Yohimbine Hydrochloride Antagonist 99.79%
    Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
  • HY-A0077
    Perphenazine Inhibitor 99.93%
    Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor (5-HT2A), Alpha-1A adrenergic receptor (α1A), Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor (H1) with Ki of 5.6, 10, 0.765/0.13, 3.4, and 8 nM.
  • HY-14300A
    Vilanterol trifenatate Agonist
    Vilanterol trifenatate is a long-acting β2-adrenoceptor2-AR) agonist with 24 h activity.
  • HY-10122
    Silodosin Antagonist 99.29%
    Silodosin (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonist with high uroselectivity; In treatment of dysuria.
  • HY-B0431A
    Phenoxybenzamine hydrochloride Antagonist >98.0%
    Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma.
  • HY-12380
    Atipamezole hydrochloride Antagonist
    Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
  • HY-14773
    Mirabegron Agonist 99.86%
    Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
  • HY-B0443A
    Xylazine hydrochloride Agonist 99.90%
    Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.