1. GPCR/G Protein
  2. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Related Products (193):

Cat. No. Product Name Effect Purity
  • HY-B0468
    Isoprenaline hydrochloride Agonist >99.0%
    Isoprenaline (hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
  • HY-13715B
    Norepinephrine bitartrate monohydrate Agonist 99.75%
    Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
  • HY-B0573
    Propranolol hydrochloride Antagonist 99.92%
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM.
  • HY-13951
    ICI 118,551 hydrochloride Antagonist 98.50%
    ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride Agonist 98.10%
    (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist primarily used as a decongestant.
  • HY-B0447B
    L-Epinephrine Agonist >99.0%
    L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.
  • HY-103207
    Amibegron hydrochloride Agonist >99.0%
    Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.
  • HY-19057A
    Vatinoxan hydrochloride Antagonist 99.25%
    Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.
  • HY-N0127
    Yohimbine Hydrochloride Antagonist 99.85%
    Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
  • HY-14773
    Mirabegron Agonist 99.08%
    Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
  • HY-B0362A
    Phentolamine mesylate Antagonist 99.83%
    Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.
  • HY-B0193A
    Prazosin hydrochloride Antagonist 99.73%
    Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.
  • HY-B0162A
    Ivabradine hydrochloride Inhibitor 98.39%
    Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
  • HY-B0976A
    Fenoterol hydrobromide Agonist 99.71%
    Fenoterol hydrobromide is a β 2 adrenergic agonist designed to open up the airways to the lungs, is classed as sympathomimetic β2 agonist and asthma medication.
  • HY-B0437
    Sotalol hydrochloride Antagonist 99.77%
    Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
  • HY-17453
    Salmeterol xinafoate Agonist
    Salmeterol xinafoate is a long-acting beta-2 adrenergic receptor (β2AR) agonist, with Ki of 1.5 nM for WT β2AR, and used for asthma treatment.
  • HY-14300A
    Vilanterol trifenatate Agonist 99.02%
    Vilanterol trifenatate is a long-acting β2-adrenoceptor2-AR) agonist with 24 h activity. The pEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.
  • HY-17416
    Guanfacine hydrochloride Agonist 99.64%
    Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.
  • HY-B0006
    Carvedilol Inhibitor 99.93%
    Carvedilol(BM14190) is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.
  • HY-B1614
    Clenbuterol hydrochloride Agonist 99.23%
    Clenbuterol hydrochloride is a β2 adrenergic receptor agonist. It is a powerful bronchodilator withfat burning properties.
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