1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. D-Mannitol

D-Mannitol  (Synonyms: Mannitol; Mannite)

Cat. No.: HY-N0378 Purity: ≥98.0%
COA Handling Instructions

D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

For research use only. We do not sell to patients.

D-Mannitol Chemical Structure

D-Mannitol Chemical Structure

CAS No. : 69-65-8

Size Price Stock Quantity
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10 mM * 1 mL in Water USD 61 In-stock
Estimated Time of Arrival: December 31
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500 mg USD 55 In-stock
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5 g USD 66 In-stock
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10 g USD 106 In-stock
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50 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator. Target: Others D(-)Mannitol is a sugar alcohol that can be used as an inert osmotic control substance. The uptake and phosphorylation of d-mannitol is catalyzed by the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase systems (PTS). Mannitol can interact with neutrophils and monocytes. Experiments have shown that it is able to decrease neutrophil apoptosis in vitro. The compound has been used in studies as a stimulator of cecal microbial growth and cellulolytic activity in rabbits. It has been observed that mannitol can lower the fat digestibility and body fat accumulation in both normal and cecectomized rats, as well as upregulate monocyte HLA-DR, monocyte and neutrophil CD11b. Studies show that the mannitol operon is repressed by the transcription factor, mannitol operon repressor (MtlR) in Escherichia coli [1-3].

IC50 & Target

Microbial Metabolite


Human Endogenous Metabolite


Clinical Trial
Molecular Weight






Structure Classification

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 36 mg/mL (197.62 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4894 mL 27.4469 mL 54.8938 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL
10 mM 0.5489 mL 2.7447 mL 5.4894 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (548.94 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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