D-Mannitol-d8
Based on 1 Customer Validation
D-Mannitol-d8 is the deuterium labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
For research use only. We do not sell to patients.
- Purity: 99.86%
- Formula: C6H6D8O6
- Molecular Weight:190.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 69-65-8
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Appearance Solid
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Molecular Weight 190.22
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Formula C6H6D8O6
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SMILES
OC([2H])([2H])[C@](O)([2H])[C@](O)([2H])[C@@](O)([2H])[C@@](O)([2H])C([2H])([2H])O
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Synonyms
Mannitol-d8; Mannite-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (262.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9. [Content Brief]
[2]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51. [Content Brief]
[3]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62. [Content Brief]
[4]. Xiao J, et al. Sakaguchi E. Mannitol improves absorption and retention of calcium and magnesium in growing rats. Nutrition. 2013;29(1):325-331. [Content Brief]
[5]. Kaufmann AM, et al. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992;77(4):584-589. [Content Brief]
[6]. Paczynski RP, et al. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28(7):1437-1444. [Content Brief]
[7]. Jeon HJ, et al. D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism. Cells. 2021;10(4):768. Published 2021 Mar 31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.2571 mL | 26.2854 mL | 52.5707 mL | 131.4268 mL |
| 5 mM | 1.0514 mL | 5.2571 mL | 10.5141 mL | 26.2854 mL | |
| 10 mM | 0.5257 mL | 2.6285 mL | 5.2571 mL | 13.1427 mL | |
| 15 mM | 0.3505 mL | 1.7524 mL | 3.5047 mL | 8.7618 mL | |
| 20 mM | 0.2629 mL | 1.3143 mL | 2.6285 mL | 6.5713 mL | |
| 25 mM | 0.2103 mL | 1.0514 mL | 2.1028 mL | 5.2571 mL | |
| 30 mM | 0.1752 mL | 0.8762 mL | 1.7524 mL | 4.3809 mL | |
| 40 mM | 0.1314 mL | 0.6571 mL | 1.3143 mL | 3.2857 mL | |
| 50 mM | 0.1051 mL | 0.5257 mL | 1.0514 mL | 2.6285 mL | |
| 60 mM | 0.0876 mL | 0.4381 mL | 0.8762 mL | 2.1904 mL | |
| 80 mM | 0.0657 mL | 0.3286 mL | 0.6571 mL | 1.6428 mL | |
| 100 mM | 0.0526 mL | 0.2629 mL | 0.5257 mL | 1.3143 mL |
D-Mannitol-d8 Related Classifications
HY-N0378S Related Classifications
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