1. Apoptosis
  2. Bcl-2 Family

Bcl-2 Family

Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, Bad, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. Human genes encoding proteins that belong to this family include: Bak1, Bax, Bal-2, Bok, Mcl-1.

Bcl-2 Family Isoform Specific Products:

  • Bax

  • Bcl-xL

  • Bcl-2

  • Bcl-W

  • Bcl-B

  • Bfl-1

  • Mcl-1

  • Bim

  • Bak

Bcl-2 Family Related Products (33):

Cat. No. Product Name Effect Purity
  • HY-15531
    ABT-199 Inhibitor 99.80%
    ABT-199 is a highly potent, orally bioavailable and Bcl-2-selective inhibitor with Ki of <0.01 nM.
  • HY-10087
    Navitoclax Inhibitor 99.80%
    Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (Ki < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-xL, Bcl-2 and Bcl-w.
  • HY-100741
    S63845 Inhibitor 99.77%
    S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.
  • HY-50907
    ABT-737 Inhibitor 98.38%
    ABT-737 is a BH3 mimetic inhibitor of Bcl-xLBcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively, and shows no inhibition against Mcl-1, Bcl-B or Bfl-1.
  • HY-12468
    A-1210477 Inhibitor 98.89%
    A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and >660 nM, respectively.
  • HY-16014
    A-385358 Inhibitor 99.05%
    A-385358 is a selective inhibitor of Bcl-XL with Kis of 0.80 and 67 nM for Bcl-XL and Bcl-2, respectively.
  • HY-19725
    A-1155463 Inhibitor 98.55%
    A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell.
  • HY-10969
    Obatoclax Antagonist 99.20%
    Obatoclax is an inhibitor targeting all antiapoptotic BCL-2 with a Ki of appr 220 nM.
  • HY-15607A
    WEHI-539 hydrochloride Inhibitor
    WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
  • HY-P0081
    Bax inhibitor peptide V5 Inhibitor 99.79%
    Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
  • HY-19741
    A-1331852 Inhibitor 99.21%
    A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
  • HY-N0087
    Gambogic Acid Inhibitor 99.86%
    Gambogic acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic acid inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
  • HY-18628
    UMI-77 Inhibitor 98.04%
    UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
  • HY-17510
    Gossypol acetic acid Inhibitor 99.42%
    Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
  • HY-15341
    BAM7 Activator 99.57%
    BAM7 is a direct and selective activator of proapoptotic BAX with an IC50 of 3.3 μM.
  • HY-15464A
    AT-101 acetic acid Inhibitor
    AT-101 acetic acid is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
  • HY-12011
    HA14-1 Inhibitor >98.0%
    HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.
  • HY-102027
    FX1 Inhibitor >98.0%
    FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
  • HY-15613
    Marinopyrrole A Inhibitor 99.94%
    Marinopyrrole A is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
  • HY-12527
    Pyridoclax Inhibitor
    Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.
Isoform Specific Products

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