1. Apoptosis
  2. Bcl-2 Family

MIK665 (Synonyms: S-64315)

Cat. No.: HY-112218 Purity: >98.0%
Handling Instructions

MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM.

For research use only. We do not sell to patients.

MIK665 Chemical Structure

MIK665 Chemical Structure

CAS No. : 1799631-75-6

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5 mg USD 350 Get quote
10 mg USD 550 Get quote
50 mg USD 1650 Get quote

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Description

MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM[1].

IC50 & Target[1]

Mcl-1

1.81 nM (IC50)

In Vitro

MIK665 (S-64315) inhibits H929 cell with an IC50 of 250 nM[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (142.79 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1423 mL 5.7116 mL 11.4232 mL
5 mM 0.2285 mL 1.1423 mL 2.2846 mL
10 mM 0.1142 mL 0.5712 mL 1.1423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.38 mM); Clear solution

References
Molecular Weight

875.41

Formula

C₄₇H₄₄ClFN₆O₆S

CAS No.

1799631-75-6

SMILES

OC([[email protected]@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[[email protected]]([[email protected]]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
MIK665
Cat. No.:
HY-112218
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MIK665

Cat. No.: HY-112218