1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-xL Inhibitors

Bcl-xL Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform Bcl-xL together.

Please try each isoform separately.

Bcl-xL Specific Inhibitors & Antagonists
Product Name Bcl-xL Bcl-2 Bcl-W Mcl-1 Bfl-1 Bcl-B Bak Bim Bcl-xL Selectivity Purity
A-1331852
Bcl-xL, Ki: 0.01 nM
Bcl-2, Ki: 6 nM
Bcl-W, Ki: 4 nM
Mcl-1, Ki: 142 nM
        Selective Inhibitor 99.81%
XZ739
Bcl-xL, DC50: 2.5 nM
              Selective Inhibitor 98.25%
A-1155463
Bcl-xL, Ki: 0.01 nM
Bcl-2, Ki: 80 nM
            Selective Inhibitor 99.62%
WEHI-539 hydrochloride
Bcl-xL, IC50: 1.1 nM
              Selective Inhibitor 98.16%
Gossypol (acetic acid)
Bcl-xL, Ki: 0.5-0.6 μM
Bcl-2, Ki: 0.2-0.3 mM
            Selective Inhibitor 99.41%
Gossypol
Bcl-xL, Ki: 0.5-0.6 μM
Bcl-2, Ki: 0.2-0.3 mM
            Selective Antagonist 99.03%
A-385358
Bcl-xL, Ki: 0.8 nM
Bcl-2, Ki: 67 nM
            Selective Inhibitor 98.63%
Navitoclax-piperazine
Bcl-xL
              Selective Inhibitor 98.83%
Bak BH3
Bcl-xL
              Selective Antagonist
Venetoclax
Bcl-xL, Ki: 48 nM
Bcl-2, Ki: 0.01 nM
Bcl-W, Ki: 245 nM
          Pan Inhibitor 99.96%
Navitoclax
Bcl-xL, Ki: 1 nM
Bcl-2, Ki: 1 nM
Bcl-W, Ki: 1 nM
          Pan Inhibitor 99.97%
ABT-737
Bcl-xL, EC50: 78.7 nM
Bcl-2, EC50: 30.3 nM
Bcl-W, EC50: 197.8 nM
   
Bcl-B, EC50: 1820 nM
    Pan Inhibitor 99.59%
Obatoclax Mesylate
Bcl-xL, Ki: 1-7 μM
Bcl-2, Ki: 220 nM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
    Pan Inhibitor 99.74%
S55746
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
            Pan Inhibitor 99.03%
Gambogic Acid
Bcl-xL, IC50: 1.47 μM
Bcl-2, IC50: 1.21 μM
Bcl-W, IC50: 2.02 μM
Mcl-1, IC50: 0.79 μM
Bfl-1, IC50: 1.06 μM
Bcl-B, IC50: 0.66 μM
    Pan Inhibitor 95.06%
TW-37
Bcl-xL, Ki: 1110 nM
Bcl-2, Ki: 290 nM
 
Mcl-1, Ki: 260 nM
        Pan Inhibitor 98.50%
(R)-(-)-Gossypol acetic acid
Bcl-xL, Ki: 480 nM
Bcl-2, Ki: 260 nM
 
Mcl-1, Ki: 170 nM
        Pan Inhibitor 98.02%
AZD4320
BCLxL, IC50: 17 nM (KPUM-UH1 cells)
BCL2, IC50: 17 nM (KPUM-UH1 cells)
            Pan Inhibitor 99.10%
BH3I-1
Bcl-xL
Bcl-2
       
Bak
Bim
Pan Inhibitor >98.0%
(R)-(-)-Gossypol
Bcl-xL, Ki: 480 nM
Bcl-2, Ki: 260 nM
 
Mcl-1, Ki: 170 nM
        Pan Inhibitor
(S)-Gossypol acetic acid
Bcl-xL
Bcl-2
            Pan Inhibitor >98.0%
Sabutoclax
Bcl-xL, IC50: 0.31 μM
BCL2, IC50: 0.32 μM
 
Mcl-1, IC50: 0.2 μM
Bfl-1, IC50: 0.62 μM
      Pan Inhibitor
Obatoclax
Bcl-xL, Ki: 1-7 μM
BCL2, Ki: 200 nM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
    Pan Inhibitor
Bcl-2-IN-2
Bcl-xL, IC50: 43 nM
Bcl-2, IC50: 0.034 nM
            Pan Inhibitor
(+)-Apogossypol
Bcl-xL, EC50: 3.69 μM
Bcl-2, EC50: 2.8 μM
 
Mcl-1, EC50: 2.6 μM
        Pan Inhibitor