VEGFR-3
VEGFR-3 (Flt-4) is the lymphatic-endothelial receptor of the VEGFR family, activated by proteolytically processed VEGF-C and VEGF-D rather than by VEGF-A. Signaling through VEGFR-3 governs lymphangiogenesis and the maintenance of lymphatic vessels during development and in adult tissue remodeling. In cancer, tumor-associated lymphangiogenesis via the VEGF-C/VEGFR-3 axis promotes lymphatic invasion and nodal metastasis, and VEGFR-3 expression also appears in some tumor blood vessels and in Kaposi sarcoma-associated lesions. A soluble VEGFR-3 isoform functions as a natural ligand trap. Recombinant VEGFR-3 supports research on lymphatic biology and on anti-metastatic therapies targeting VEGF-C signaling.
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VEGFR-3 Recombinant Proteins (7)
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Inhibitors & Agonists (70)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
