VEGFR-3/FLT4 Protein, Mouse (HEK293, His)

VEGFR-3/FLT4 proteins are tyrosine protein kinase receptors for VEGFC and VEGFD and are critical in adult lymphangiogenesis and embryonic vascular development. It promotes endothelial cell function, angiogenesis, and forms a positive feedback loop that increases VEGFC production. VEGFR-3/FLT4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-3/FLT4 Protein, Mouse (HEK293, His) is 751 a.a., with molecular weight of 95-105 kDa.

VEGFR-3/FLT4 protein, a tyrosine-protein kinase, functions as a cell-surface receptor for VEGFC and VEGFD, playing a pivotal role in adult lymphangiogenesis and contributing significantly to the development of the vascular network and cardiovascular system during embryonic development. Its diverse functions include promoting the proliferation, survival, and migration of endothelial cells, along with the regulation of angiogenic sprouting. Activation of FLT4 leads to an augmented production of VEGFC and, to a lesser extent, VEGFA, establishing a positive feedback loop that enhances FLT4 signaling. Additionally, VEGFR-3/FLT4 modulates KDR signaling through the formation of heterodimers. Its signaling cascade involves the activation of the MAPK1/ERK2, MAPK3/ERK1, MAPK8, and JUN pathways, as well as the AKT1 pathway. VEGFR-3/FLT4 phosphorylates SHC1 and mediates the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Furthermore, it promotes the phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185,' as well as AKT1 at 'Ser-473,' underscoring its integral role in orchestrating complex signaling events crucial for lymphangiogenesis and vascular development.

Mouse

HEK293

C-His

P35917 (Y25-E775)

14257  [NCBI]

95-105 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.